Results: Three hundreds and one patients were enrolled. Nine patients (3%) were lost to follow-up at one year. The rates of thrombotic and bleeding events at one year were 7.5 and 6.8% respectively. The mean VASP index after a 60 mg LD of prasugrel was 34}23% and 76 patients (25%) were considered as having high on-treatment platelet reactivity (HTPR). Patients with HTPR had a higher rate of thrombotic events compared to good responders (19.7 vs 3.1%;p<0.001). Patients with a minor or major non-CABG related TIMI bleeding had lower PR compared to patients with no bleeding events (21}18 vs 35}23%;p=0.008). In multivariate analysis, the VASP index predicted both thrombotic and bleeding events (OR: 1.44 (95% CI: 1.2-1.72; p<0.001 and 0.75 (95% CI: 0.59-0.96;p=0.024 (respectively, per 10% increase)).

In the paper, we have analysed curricula of the several subjects in lower grades of the primary school in Republika Srpska. Blum's taxonomy was used in the analysis (cognitive and psycho-motor area) and SMART system of evaluating learning outcomes. There have been three subject areas included (the world around us, speech, expression, crating and rhythm, sport and music), in the first grade ten subjects (Serbian, Mathematics, Natural and Social Sciences, etc.), and pedagogical work with the class, which are being studied from the second to the fifth class. The aim of the analysis was to determine knowledge and skills which students should gain in the lower grades of the primary school. We have achieved this aim by determination of the outcomes adequacy based on the above stated criteria, levels of knowledge and skills, which are required, as well as estimation of how much each teaching unit requires certain level of students' knowledge and whether there is the trend of more requirements when passing one grade and entering the other. The results of the analysis show that students are required the lowest level of understanding and gaining (on average 60% of outcomes are on this level), and higher levels require only application (about 15%). This relation varies, depending on the subject. When we talk about skills, they are at the level of precision, and this is sufficient for this age. The rising requirements for students, through learning outcomes have not been observed, because from grade to grade the outcomes are on the same level. This means that we do not work sufficiently at the quality improvement, but on quantity improvement of knowledge.

Processes in product development are becoming more and more complex. A multitude of engineering disciplines are involved in the development of new products. New lean and agile methods arise. Pulse methodology is a lean deviation management methodology introduced by Scania in 2003, and since then many Swedish companies adapted it. It is based on synchronizing the company by frequently having short meetings (aka. pulse meetings) and visualizing the deviations using traffic coded magnets on whiteboards (aka. pulse boards). Even though the whiteboards lack providing efficient communication between distributed teams, still the users appreciate the simplicity of them. In this research, we presented a new methodology called hybrid pulse methodology, which solves the communication issues exist in the baseline methodology. We tested the methodology at the workshops we held in the companies, in simulated global meeting settings, using the demonstrator we developed for the methodology. This research contributes to the lean literature with a new methodology that ensures the synchronization of global organizations by providing efficient communication between distributed teams without damaging the baseline methodology.

Abstract Laser beam machining (LBM) is one of the most widely used thermal energy based non-contact type advance machining process which can be applied for almost whole range of materials. This paper defines mathematical models for surface roughness prediction (Ra, μm) and width of heat affected zone (HAZ, mm) during laser cutting of alloy steels 1.4571 and 1.4828 with nitrogen as assist gas. For defining appropriate mathematical models multiple regression analysis is used with four independent variables. Following parameters are varied: cutting speed, focus position, nitrogen assist gas pressure and stand-off. Obtained mathematical models describe dependence of Ra and HAZ from varied process parameters.

Abstract This paper deals with modeling and simulation of multibody systems consisting of rigid and flexible bodiesactuated by hydraulic motors. To develop the corresponding modelbond graph technique is used thatprovides a systematic component oriented methodology. The proposed procedure is explained on the example of arotary crane.The simulation model was developed and simulation conducted using BondSim© program. The model developed is based on physical modeling philosophy by systematically decomposing it into the components and using the models from theprogram library. Mathematical model of the system may be machine generated in the form of differential algebraic equations (DAEs) and solved using a solver capable of solving such models up to semi implicit index two models.

Abstract In the present paper, experimental study is made to investigate the effect of cutting parameters on surface roughness in dry high speed milling of hardened tool steel using two cutting tools (diameter of 20 and 40 mm). The cutting parameters considered include cutting speed and feed per tooth. Experiments are conducted in up-cut and down-cut milling. Based on the experimental data, the effect of tool diameter on the surface roughness is analyzed. The good surface roughness can be achieved in high speed machining of examined steel but rapidly tool wear is observed.