Abstract The paper deals with metonymies having body parts as source domains in English and Bosnian. According to Cognitive Linguistics standpoint, human cognition is based on bodily functioning. Therefore, we started from the hypothesis that most body part metonymies are very similar across languages and cultures, and share similar properties. The aim of the paper was threefold: first, to examine whether metonymies with body parts as source domains have common grammatical and conceptual properties in English, secondly to examine whether they share the same properties in Bosnian, and thirdly to compare the two languages in this respect. We analysed body part metonymies in terms of some grammatical properties such as the use of singular and plural, specific and generic reference, grammatical recategorisation from count to mass nouns, noun-to-verb conversion, and some conceptual properties such as source-in-target vs. target-in-source metonymies, metonymic chains and combination of metaphor and metonymy. Many common features were found both within the respective languages under consideration and in cross-linguistic analysis. The minor differences found in contrasting the data from the two languages are mainly the result of differences in grammatical systems.

Aim: This study sought to assess whether the volume and osmolarity of contrast media (CM) influences the occurrence of contrast induced nephropathy (CIN) following coronarography procedure. CIN can be defined as an increase in the serum concentration of creatinine greater than a 25% from baseline during the period of 12 to 48 hours after the administration of radiocontrast media. Material and methods: We examined 100 patients without diabetes with serum creatinine concentration from 45 mmol/l to 141 mmol/l and 100 patients with diabetes with serum creatinine concentration from 46 mmol/l to 161 mmol/l who underwent coronary angiography. During procedure they received iso-osmolar contrast medium, Visipaque 320 (iodixanol-320), for group without diabetes from 40 to 340 ml and for group with diabetes from 49 to 310 ml. Results: CIN occurred in 27 (13,5%) of the 200 study patients. There was a trend toward higher prevalence of CIN (16% vs.11%, p = 0.086) in the diabetic group compared with the non-diabetic group. Patient with diabetes received less contrast media, they are younger but number patients with CIN are higher. Conclusion: Increasing contrast media dose is associated with the occurrence of CIN following coronarography. But, another risk factors like diabetes mellitus, old age, male sex and preexisting kidney disease have influence of developing CIN after coronarography.

Background/Aims: Residual renal function (RRF) has been shown to influence survival of peritoneal dialysis (PD) patients. This study examined the relations between RRF and left ventricular hypertrophy (LVH) before switching on dialysis treatment and observed during 18 months on PD treatment. Methods: A prospective longitudinal study was performed in 50 non-anuric (defined as >200 mL urine output in a 24-hour period) PD patients. Echocardiography, RRF and other known risk factors for the increase of LV mass index (LVMi) were determined at study baseline and the end of follow-up. Results: There was 78% patients with LVH in end-stage renal disease (ESRD) baseline and 60% at the end of follow-up. RRF at the start of the study showed no significant difference between patients with normal and increased LVMi, as well as in daily collection of urine. After 18 months, patients with decreased LVMi had better RRF, lower CRP and better Kt/V compared to patients with increased LVMi (p < 0.001). Patients with better preserved RRF not only had significantly higher total Kt/V, but were less anemic and hypoproteinemic and lesser presence of LVH. Conclusions: PD in non-anuric ESRD patients the first 18 months has a positive effect on the preservation of RRF and partial regression of left ventricular remodeling.

Introduction: Starting from the point that the chronic kidney disease (CKD) is chronic, inflammatory and hypercoagulable state characterized by an increase in procoagulant and inflammatory markers high cardiovascular morbidity and mortality in these patients could be explained. Aim: The aim of the research was to monitor inflammatory markers and procoagulants in various stages of kidney disease (stage 1-4). Materials and Methods: The research included 120 subjects older than 18 years with CKD stages 1-4 examined and monitored in Clinic of Nephrology, University Clinical Centre Sarajevo over a period of 24 months. The research included determining the following laboratory parameters: serum creatinine, serum albumin, C-reactive protein, leukocytes in the blood, plasma fibrinogen, D-dimer, antithrombin III, coagulation factors VII (FC VII) and coagulation factor VIII (FC VIII). Results: With the progression of kidney disease (CKD stages 1-4), there was a significant increase of inflammatory and procoagulant markers: CRP, fibrinogen and coagulation factor VIII, and an increase in the average values of leukocytes and a reduction in the value of antithrombin III, but without statistical significance. Also, there were no significant differences in the values of D-dimer and coagulation factor VII. Conclusion: The progression of kidney disease is significantly associated with inflammation, which could in the future be useful in prognostic and therapeutic purposes. Connection of CKD with inflammation and proven connection of inflammation with cardiovascular risk indicates the potential value of some biomarkers, which could in the future identify as predictors of outcome and could have the benefit in the early diagnosis and treatment of cardiovascular disease in CKD.

Intr Heart rate variability has been recognized as a parameter that partly describes autonomic nervous system modulation of cardiovascular system.Analysis of heart rate variability has been proposed as clinically important as predictive and monitoring factor in subjects with different cardiac disease conditions and in subjects who suffer from diabetes mellitus. Despite numerous clinical and experimental trials on the topic of heart rate variability in the setting of intensive care medicine there is a lack of appropriate technological facilites for routine monitoring and analysis of this phenomenon in everyday clinical practice.

E-mail still proves to be very popular and an efficient communication tool. Due to its misuse, however, managing e-mails problem for organizations and individuals. Spam, known as unwanted message, is an example of misuse. Specifically, spam is defined as the arrival of unwelcomed bulk email not being requested for by recipients. This paper compares different Machine Learning Techniques classification of spam e-mails. Random Forest (RF), C4.5 and Artificial Neural Network (ANN) were tested to determine which method provides the best results in spam e-mail classification. Our results show that RF is the best technique applied on dataset Labs, indicating that ensemble methods may have an edge in spam detection effective susceptible to is spam, also is defined messages not istaken with or religious he most email by a . Furthermore, by spam. around (which makes (Grant, 2003; Every e-mail user in America received an average of 2200 pieces of spam e-mails in 2002. In 2007 it reached 3600 pieces of spam e-mails due to increase rate of 2% per month conducted a survey revealing that a Chinese spam e-mails weekly. Due to spam e enterprises lose up to 9 billion yearly reveal that spam e-mails take about 60% of the incomin in a corporate network. With inappropriate or no countermeasures, the situation will worsen and, in the end, spam e-mails may destruct the usage of e countries are slowly starting to use anti (Gaikwad & Halkarnikar, 2014). The main argument supporting spam increase is the fact that spammers do not have any costs for it: “Because email technology allows spammers to shift the costs almost entirely to third parties, there is no incentive for the spammers to reduce the volume” (Hann, Hui, Lai, Lee, & Png, 2006) issue for spam is the annoying content they carry significant amount of spam contains some offensive materials (Maria & Ng, 2009). In China, some specialists suggest spam email measure as early as possible. However, because of 1210 Sarajevo,

Luka Kovacic Luka, MD, PhD, passed away in Zagreb on April 21st, 2015. He was specialist in Social medicine and organization of health care. Luka Kovacic graduated from the School of Medicine in Zagreb in the year 1965, and after a few years of medical practice he joined the Andrija Stampar School of Public Health in Zagreb. He earned both, MSc and PhD degree from the University of Zagreb School of Medicine in 1972 and 1983, and he advanced in academic career from the assistant position in the Chair for hygiene, social medicine, and epidemiology to full professorship in 2003. He was also trained in Sweden (1964), Scotland (1966), USA (1968 and 1971 when he was trained in Public Health, Epidemiology and Research Methods at the Johns Hopkins School of Hygiene and Public Health in Baltimore), Finland (University of Kuopio, 1977) and Alma-Ata (WHO training in Planning and Management in 1985). He paid study visits or served as a consultant in the UK, the USSR, Kazakhstan, Sudan, Cameroon, India, Iran (UNDP), Nigeria (WHO) and elsewhere. At the Andrija Stampar School of Public Health he used to held numerous posts and responsibilities: he was a head of the Department for Hygiene, Social Medicine and Epidemiology 1993-1997 and continued to head the Department for social medicine and organization of health care and was director of the Andrija Stampar School of Public Health till his retirement in 2006; he was deputy coordinator from 1984 and coordinator 1997-2000 of the WHO Collaborating Centre for primary health care; he served as an assistant to the director and deputy director (1984-2004). He served firstly as the coordinator and later as director (1990-1996) of the International 9-week course “Planning and management of primary health care in developing countries” which was held 16 times between 1978 and 1996 at the Andrija Stampar School of Public Health with the support of the Government of the Netherlands and had altogether more than 350 participants coming form 66 countries. His activities and duties were so numerous both within his institution and in the broader Croatian and international public health and medical community that we mentioned only those mostly pronounced or internationally visible. Luka was gifted and dedicated teacher, mentor of six MSc theses and one PhD dissertation as well as altogether more than 200 diploma works for medical and nursing students at the School of Medicine and School of Applied Health Sciences. He was principal investigator in many domestic projects and played a leading role in several international projects and networks. He actively participated in the work of the European network of districts “Tipping the Balance Toward Primary Health Care” (TTB) from 1987, being also its Chairman of the Board and president of the Assembly from 1997 to 2005 and the coordinator of the whole network and the project “TTB Second Decennial Survey of the Health Needs and Health Care for Older People in Europe”, which was implemented in five European countries including Croatia in 2005-2006. He was also a member of the European Society for Public Health and its Scientific Committee since 2000. Professor Luka Kovacic had coordinative role and contributed enormously to the establishment of the Forum for Public Health in South Eastern Europe (FPH-SEE) as a network of academic institutions aimed for the reestablishment of professional cooperation between public health teachers and professionals in SEE. As the result of this cooperation six books were prepared and published between 2004 and 2010 encompassing altogether more than 4300 pages, containing some 250 teaching modules authored by more than 200 authors, among them professor Kovacic co-edited the volume “Management in Health Care Practice” and authored four modules only within it. He has published almost 200 scientific and professional articles and edited several books and authored a few textbooks, among them also a textbook in Social Medicine. He coordinated a number of national and international projects and networks, has organized numerous national and international conferences in the field of public health and health care organization. As Public health expert and educator Luka Kovacic has been a person with great treasure of warmth and experiences. He was right person from whom always you can ask advice for solving a problems. Everybody of us will miss his friendship and honesty and his students will miss his great educational lectures. Sarajevo, September 2015

Introduction: Stroke is a rapid loss of brain function due to disturbance blood flow to the brain. The existence of multiple risk factors, the length of their duration, and severity of each factor individually, is positively correlated with the occurrence of stroke. Stroke is the third cause of disability and premature death for men and women. Aim: The aim of this research is that through clinical and epidemiological studies the origin and development of stroke to inspect the same level of representation in the population of the Herzegovina-Neretva Canton. Material and methods: This survey covers the entire population of residents in the Herzegovina-Neretva Canton, and the number of patients who had a need for primary and secondary treating the symptoms of stroke. The very setting of this model of anthropological research modern human groups and theoretical estimates of the impact of genetic and / or environmental risk factors in the formation of phenotypic expression of complex traits of stroke, at the population level, resulted in the realization of the very methodology of this research. The study was conducted at the Department of Neurology, Regional Medical Center (RMC) “Dr. Safet Mujic” and the Department of Neurology, Clinical Center Mostar. These two health institutions, in addition to primary care are at the disposal for entire population of the Herzegovina-Neretva Canton and beyond. Data were collected by examining the details of the history of the board of hospitalized patients in the period from 1 January 2010–to 31 December 2014. The processed are 10 risk factors–potential causes of stroke. We also as research material, used records of hospital morbidity–the disease-illness statistics form (form number: 03-21-61; 03/02/60; 03/02/61; 09/03/60). Results: In our study, stroke is the second most frequent in the period of investigation, and noted the rapid growth that is in 2010 and 10.21% to 14.52% in 2014. There was a slight statistically significant differences in relation to the number of infected men and women, and the same is in favor of the patients are female. The number of patients with ischemic stroke, 954 of them or 48.38% was male and 1,018 or 51.62% were female. Of the 10 possible risk factors, factor 6 has a statistically significant canonical factor value, of which hypertension–CVI and the level of P = 0009 *, p = secondary hypertension, 0034 *, hypertensive heart disease, p =, * 0021, Diabetes mellitus of P = 0029 *, p = Anemia, 0052 * and C-reactive protein (CRP) of p = 0049 *, respectively, these canonical factors carry the entire amount of information about the relations impact of certain risk factors in the onset and development of the brain shock. Conclusion: We conclude that there is a statistically significant correlation between the studied risk factors in the genesis of the origin and development of different types of stroke.

Jean–Raoul Scherrer (1932 - 2002) was a pioneer in the development and deployment of clinical information systems (1, 2, 3). He received in 2000 the Morris F. Collen Award of Excellence in medical informatics. Jean-Rauol Scherrer was born in the Canton of Jura, Switzerland, in October 1932 but has lived most of his life in Geneva, Switzerland. He went to college in Fribourg, at a Jesuit School called College of Saint Michel, and followed the classical pathway - ancient Greek, Latin, and strong mathematics studies. In 1959, he graduated from the Medical School of the University of Geneva, where he studied Physiology and Internal medicine. From 1967 until 1969, Professor Scherrer did postgraduate work in Medical physics at Brookhaven National Laboratory, on Long Island, and then returned to Geneva and the Cantonal Hospital of the University of Geneva, where he began to design and build what was to become DIOGENE, the Hospital’s patient information system. The idea was to have a system that would be patient-centric. Professor Scherrer addressed the needs of the physician, and not only that, he did not encumber the physician with the need to learn the computer (1). The basic principle was : One puts orders in through the telephone. One could immediately see on the screen what he had ordered. Behind this outward facade was a bank of individuals who were keying in the information for orders, for medications, for laboratory work, and for radiology. But his objective was to see how the computer could be an enabling tool, to assist the health care provider in doing what he or she needed to do to be giving the best possible care for the patient. Starting with the mainframe-based patient-centered hospital information system DIOGENE in the 70s, Prof. Scherrer developed, implemented and evolved innovative concepts of man-machine interfaces, distributed and federated environments, leading the way with information systems that obstinately focused on the support of care providers and patients. Through a rigorous design of terminologies and ontologies, the DIOGENE data would then serve as a basis for the development of clinical research, data mining, and lead to innovative natural language processing techniques. In parallel, Prof. Scherrer supported the development of medical image management, ranging from a distributed picture archiving and communication systems (PACS) to molecular imaging of protein electrophoreses (2). Recognizing the need for improving the quality and trustworthiness of medical information on the Web, Prof. Scherrer created the Health-On-the-Net (HON) foundation. He had groups working on natural language processing and image processing and manipulation in the OSIRIS system. Another of his groups was determining protein constellations in human patients by the use of bi-dimensional electrophoresis of human serum, and correlating these patterns with the identification of genes, using several scattered remote data bases. This Web-based system is called ExPASy. This was one of the first bioinformatics groups assembled any place in the world. In Geneva in 1992, researchers at CERN, a high-energy physics laboratory, invented the World Wide Web. Luckily, the director of CERN was a neighbor of Professor Scherrer, and because of this neighborhood collaboration, the group at Geneva Hospital was really the first to apply World Wide Web technology in health care. They made their protein research databases available to colleagues around the world via the Web and were really the first to do this. Dr. Scherrer was Executive Vice President of IMIA (International Medical Informatics Association) in charge of Working Groups and Special Interest Groups from 1993 to 1996: and President of the EFMI (1996-1998) (2). Figure 1 Scherrer Jean-Raoul (1932.-2002.)