In this note we derive a simple Bayesian sampler for linear regression with the horseshoe hierarchy. A new interpretation of the horseshoe model is presented, and extensions to logistic regression and alternative hierarchies, such as horseshoe+, are discussed. Due to the conjugacy of the proposed hierarchy, Chib's algorithm may be used to easily compute the marginal likelihood of the model.

Haloquadratum walsbyi represents up to 80 % of cells in NaCl-saturated brines worldwide, but is notoriously difficult to maintain under laboratory conditions. In order to establish the extent of genetic diversity in a natural population of this microbe, we screened a H. walsbyi enriched metagenomic fosmid library and recovered seven novel version of its cell-wall associated genomic island. The fosmid inserts were sequenced and analysed. The novel cell-wall associated islands delineated two major clades within H. walsbyi. The islands predominantly contained genes putatively involved in biosynthesis of surface layer, genes encoding cell surface glycoproteins and genes involved in envelope formation. We further found that these genes are maintained in the population and that the diversity of this region arises through homologous recombination but also through the action of mobile genetic elements, including viruses. The population of H. walsbyi in the studied saltern brine is composed of numerous clonal lineages that differ in surface structures including the cell wall. This type of variation probably reflects a number of mechanisms that minimize the infection rate of predating viruses.

BackgroundHaloquadratum walsbyi represents up to 80 % of cells in NaCl-saturated brines worldwide, but is notoriously difficult to maintain under laboratory conditions. In order to establish the extent of genetic diversity in a natural population of this microbe, we screened a H. walsbyi enriched metagenomic fosmid library and recovered seven novel version of its cell-wall associated genomic island. The fosmid inserts were sequenced and analysed.ResultsThe novel cell-wall associated islands delineated two major clades within H. walsbyi. The islands predominantly contained genes putatively involved in biosynthesis of surface layer, genes encoding cell surface glycoproteins and genes involved in envelope formation. We further found that these genes are maintained in the population and that the diversity of this region arises through homologous recombination but also through the action of mobile genetic elements, including viruses.ConclusionsThe population of H. walsbyi in the studied saltern brine is composed of numerous clonal lineages that differ in surface structures including the cell wall. This type of variation probably reflects a number of mechanisms that minimize the infection rate of predating viruses.

The approach of metric-affine gravity initially distinguishes it from Einstein’s general relativity. Using an independent affine connection produces a theory with 10

During the war in Bosnia and Herzegovina (1992–1995) cultural heritage was explicitly targeted and the state of destruction was extensive to both sacral and secular monuments. Two decades after the end of hostilities the perception of the historic environment is still defined from the angles of national, religious or ethnic belonging. Enabling recognition, reconciliation, tolerance and respect within the community of Stolac, Bosnia & Herzegovina through a better understanding and sharing of cultural heritage was the focus of this project. Stolac is representative of the problems in the region and stands out for its particularly sharp divisions. Until recently there was segregation with local schools and their curriculum was divided with cultural heritage generally not addressed. How can this small community engage with heritage and develop a dialogue that encourages tolerance, respect and as a base for development? How does one understand, then document areas significance to the community? Finally, how can technology assist? The focus of this paper is to relate the experiences and findings of a project that incorporated participatory imaging mapping and the use of technology to bridge between the internal borders of this small community. It will outline a methodology, experiences of the participants and results from their exercises in order to assist other communities facing similar issues.