The Slavic branch of the Balto-Slavic sub-family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion–mainly to East Europe and the northern Balkans–resulted in the incorporation of genetic components from numerous autochthonous populations into the Slavic gene pools. Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation. The data suggest that genetic diversity of the present-day Slavs was predominantly shaped in situ, and we detect two different substrata: ‘central-east European’ for West and East Slavs, and ‘south-east European’ for South Slavs. A pattern of distribution of segments identical by descent between groups of East-West and South Slavs suggests shared ancestry or a modest gene flow between those two groups, which might derive from the historic spread of Slavic people.

Abstract Introduction Self- assessment of oral health is simple, non-invasive and cost-effective method of collecting data that takes into account psychosocial aspects of oral health. The aim of this study was to investigate the effect of clinical factors on the self-perception of oral health in middle-aged patients in Republika Srpska (Bosnia and Herzegovina). Material and Methods The study included 126 subjects of both genders (34.1% male and 65.9% female) aged 24-54 years. Data were collected through questionnaires and clinical examination. Anonymous questionnaire contained questions related to socio-demographic characteristics of respondents. Clinical examination included teeth condition and the presence of prosthetic restorations. Self-perception of oral health was determined by one question. Results Bivariate analysis indicated significant effect of carious (p<0.001), missing (p<0.001) and filled teeth (p=0.022) but not the prosthetic status on self-perception of oral health. Correlation between the number of carious and missing teeth with self-perception of oral health was significant in regression analysis. Conclusion The number of carious and missing teeth had significant impact on self-assessment of oral health in studied population. Knowledge of effects of oral clinical variables on self-perception of oral health is very important to obtain clearer insight into the association between objectively and subjectively assessed oral health.

INTRODUCTION Electrocardiographic (ECG) diagnosis of acute myocardial infarction (AMI) in patients with paced rhythm is difficult. Sgarbossa's criteria represent helpful diagnostic ECG tool. CASE REPORT A 57-year-old female patient with paroxysmal atrial fibrillation and a permanent pacemaker presented in the Emergency Department with prolonged typical chest pain and ECG recording suggestive for AMI. Documented ECG changes correspond to the first Sgarbossa's criterion for AMI in patients with dual pacemakers (ST-segment elevation of 5 mn in the presence of the negative QRS complex). The patient was sent to catheterization lab where coronary angiogram reveled normal findings. ECG changes occurred due to pericardial reaction following two interventions: pacemaker implantation a month before and radiofrequency catheter ablation of AV junction two weeks before presentation in Emergency Department. CONCLUSION This case report points out to the limitations of proposed criteria that aid in the recognition of AMI in patients with underlying paced rhythm and possible cause(s) of transient electrocardiographic abnormalities.