This paper traces the changes in the development of the field of knowledge management (KM) over time, through a review of the representative literature and the author’s own research. The paper starts by going back to the origins of KM and reflects on three significant evolutionary stages termed fragmentation, integration and fusion. Following these reflections on the KM past, the paper speculates on the possible KM future. It identifies three emerging trends named extension, specialization and reconceptualization that point to several possible KM futures. The first two involve decentralisation and regeneration of prior KM interpretations, while the third trend signals a revolutionary next KM generation. Irrespective of the direction it may take, the evidence presented in this paper suggests that KM has a future, although it may not be without challenges.

: Aim: Evaluation of the significance of micronuclei (MN) as biomarkers for evaluation the risk of malignant transformation in uterine cervix. MN are intracytoplasmic inclusion bodies from chromatin fragments or whole chromosomes. Their presence in cells is a reflection of chromosomal aberration during cellular mitosis. Patients and methods: MN screening was done in all selected cytopathological smears (conventional Papanicolaou test) by counting 1000 cervical squamous cells with a light microscope at a magnification of 1000x. Results: Comparisons between women with progressive increases in cervical intraepithelial neoplasia (CIN) and control group. The MN frequencies observed were significantly higher in the groups with cellular changes compared to the control group. Conclusion: The results described that the MN test in cervix smears could be incorporated into routine screening procedures as an additional criterion for early detection of cytopathologocal damage. However, additional detailed, systematic studies are needed to confirm this suggestion.

The aim of this study was to determine the total phenolic content, evaluate antioxidant propertie and antimicrobial potential, and identify phenolic compounds in alcoholic and aqueous extracts of the wild cherry (Prunus avium L.) stems collected in Bosnia and Herzegovina. Alcoholic extracts had higher contents of phenolic and flavonoid components, as well as the antioxidant and ferric reducing antioxidant capacity in comparison to aqueous extracts. All extracts were characterized by HPLC analysis. Furthermore, for the first time, the antimicrobial properties of wild cherry stem extracts were evaluated. Quercetin and (+)-catechin were the main compounds identified in the alcoholic extract, followed by chlorogenic acid and rutin. Quercetin was also the major component detected in aqueous extracts. Besides, alcoholic extract showed better antibacterial properties against Staphylococcus aureus as a representative gram-positive bacteria than infusion, whereas none of the samples showed antibacterial activity against Escherichia coli and fungus Candida albicans.