Abstract The most popular measure of the National Rural Development Programme in Romania for 2007-2013 was the measure 121 addressing the support for modernisation of agriculture While the success at the level of the Programme is measured by the achievement level of the assumed indicators the present analysis is focused on differences between the volumes of proposed, selected, contracted and concluded projects. These differences as observations and findings contribute as learning points to the further use of public support for investments in agriculture by three main categories of users: the administration with the procedural enhancement in programme implementation, the beneficiaries improving their approach and readiness for applications/projects and the consultants in perfecting their tools and work to support and smoothen the resources transfer in the process.

Summary Premature loss of teeth in children may lead to both functional and esthetic problems. Missing teeth in both anterior and posterior regions may cause malfunctions in mastication and proper pronunciation. If the missing teeth are not replaced, further complications may occur, including adjacent tooth migration, loss of alveolar bone, and irregular occlusion. Considering the sensitive nature of children, loss of teeth may cause the development of insecurities and low self esteem problems. Due to dynamic nature of growth in children and adolescents, prosthetic appliances must not hinder development of orofacial system, and must meet adequate esthetic and functional standards. Dental prosthetic appliances in paediatrics must be planned with respect to the special conditions that led to tooth loss or damage. Multi-disciplinary approach is needed, under constant supervision of paediatric dentist and orthodontist, as well as regular checkups with clinical and radiographical examinations.

Abstract Objectives SB2 is a biosimilar to the reference infliximab (INF). Similar efficacy, safety and immunogenicity between SB2 and INF up to 30 weeks were previously reported. This report investigates such clinical similarity up to 54 weeks, including structural joint damage. Methods In this phase III, double-blind, parallel-group, multicentre study, patients with moderate to severe RA despite MTX were randomized (1:1) to receive 3 mg/kg of either SB2 or INF at 0, 2, 6 and every 8 weeks thereafter. Dose escalation by 1.5 mg/kg up to a maximum dose of 7.5 mg/kg was allowed after week 30. Efficacy, safety and immunogenicity were measured at each visit up to week 54. Radiographic damage evaluated by modified total Sharp score was measured at baseline and week 54. Results A total of 584 patients were randomized to receive SB2 (n = 291) or INF (n = 293). The rate of radiographic progression was comparable between SB2 and INF (mean modified total Sharp score difference: SB2, 0.38; INF, 0.37) at 1 year. ACR responses, 28-joint DAS, Clinical Disease Activity Index and Simplified Disease Activity Index were comparable between SB2 and INF up to week 54. The incidence of treatment-emergent adverse events and anti-drug antibodies were comparable between treatment groups. Such comparable trends of efficacy, safety and immunogenicity were consistent from baseline up to 54 weeks. The pattern of dose increment was also comparable between SB2 and INF. Conclusion SB2 maintained similar efficacy, safety and immunogenicity with INF up to 54 weeks in patients with moderate to severe RA. Radiographic progression was comparable at 1 year. Trial registration ClinicalTrials.gov (http://clinicaltrials.gov; NCT01936181) and EudraCT (https://www.clinicaltrialsregister.eu; 2012-005733-37)

Pulmonary surfactant (PS) reduces surface tension at the air-liquid interface in the alveolar epithelium of the lung, which is required for breathing and for the pulmonary maturity of the developing foetus. However, the origin of PS had never been thoroughly investigated, although it was assumed to be secreted from the foetal developing lung. Human amniotic membrane (hAM), particularly its epithelial cell layer, composes the amniotic sac enclosing the amniotic fluid. In this study, we therefore aimed to investigate a potential contribution of the cellular components of the hAM to pulmonary surfactant found in amniotic fluid. We identified that cells within the native membrane contain lamellar bodies and express all four surfactant proteins as well as ABCA3. Lipidomic profiling by nanoESI – MS/MS revealed the presence of the essential lipid species as found in PS. Also, the biophysical activity of conditioned cell culture supernatant obtained from hAM was tested with captive bubble surfactometry. hAM supernatant showed the ability to reduce surface tension, similar to human PS obtained from bronchoalveolar lavage. This means that hAM produces the essential PS-associated components and can therefore contribute as second potential source of PS in amniotic fluid aside from the foetal lung.

Partial wave amplitudes of meson photoproduction reactions are an important source of information in baryon spectroscopy. We investigate a new approach in single-energy partial wave analyses of these reactions. Instead of using a constraint to theoretical models in order to achieve solutions which are continuous in energy, we enforce the analyticity of the amplitudes at fixed values of the Mandelstam variable $t$. We present an iterative procedure with successive fixed-$t$ amplitude analyses which constrain the single-energy partial wave analyses and apply this method to the $\gamma p \to \eta p$ reaction. We use pseudo data, generated by the EtaMAID model, to test the method and to analyze ambiguities. Finally, we present an analytically constrained partial wave analysis using experimental data for four polarization observables recently measured at MAMI and GRAAL in the energy range from threshold to $\sqrt{s}=1.85$ GeV.

This study presents genetic data for nine Native American populations from northern North America. Analyses of genetic variation focus on the Pacific Northwest (PNW). Using mitochondrial, Y chromosomal, and autosomal DNA variants, we aimed to more closely address the relationships of geography and language with present genetic diversity among the regional PNW Native American populations. Patterns of genetic diversity exhibited by the three genetic systems were consistent with our hypotheses: genetic variation was more strongly explained by geographic proximity than by linguistic structure. Our findings were corroborated through a variety on analytic approaches, with the unrooted trees for the three genetic systems consistently separating inland from coastal PNW populations. Furthermore, analyses of molecular variance support the trends exhibited by the unrooted trees, with geographic partitioning of PNW populations (FCT = 19.43%, p = 0.010 ± 0.009) accounting for over twice as much of the observed genetic variation as linguistic partitioning of the same populations (FCT = 9.15%, p = 0.193 ± 0.013). These findings demonstrate a consensus with previous PNW population studies examining the relationships of genome-wide variation, mitochondrial haplogroup frequencies, and skeletal morphology with geography and language.

This paper proposes a new approach on the novel current control strategy for grid-tied voltage-source inverters (VSIs) with circumstances of asymmetrical voltage conditions. A standard grid-connected inverter (GCI) allows the degree of freedom to integrate the renewable energy system to enhance the penetration of total utility power. However, restrictive grid codes require that renewable sources connected to the grid must support stability of the grid under grid faults. Conventional synchronously rotating frame dq current controllers are insufficient under grid faults due to the low bandwidth of proportional-integral (PI) controllers. Hence, this work proposes a proportional current controller with a first-order low-pass filter disturbance observer (DOb). The proposed controller establishes independent control on positive, as well as negative, sequence current components under asymmetrical grid voltage conditions. The approach is independent of parametric component values, as it estimates nonlinear feed-forward terms with the low-pass filter DOb. A numerical simulation model of the overall power system was implemented in a MATLAB/Simulink (2014B, MathWorks, Natick, MA, USA). Further, particular results show that double-frequency active power oscillations are suppressed by injecting appropriate negative-sequence currents. Moreover, a set of simulation results provided in the article matches the developed theoretical background for its feasibility.

The Skindex-29 instrument, which is intended for measuring the influence of skin diseases on quality of life, was developed and validated in several languages. However, a Serbian translation of the instrument is not available. The aim of this study was to translate the Skindex-29 from English to Serbian, to make necessary cultural adaptations, and to test its psychometric properties in a sample of outpatients with various skin diseases. The Skindex-29 was translated and adapted according to internationally accepted guidelines and then tested on a sample of Serbian outpatients with various skin diseases. Internal consistency was checked through calculation of Cronbach's alpha and Interclass Correlation Coefficient for the instrument's domains. The criterion validity of the translation was tested by correlating scores of domains with scores on the Serbian version of Dermatological Life Quality Index (DLQI).Validity of the construct was tested through comparison of the domains scores in groups of patients with different skin diseases. Fifty-three patients (18.6%) suffered from acne vulgaris, 48 (16.8%) from verrucae vulgares, 40 (14.0%) from psoriasis, 34 (11.9%) from an undetermined type of mild dermatitis, 20 (7.0%) from venous ulcers, 19 (6.7%) from eczema, and 71 (24.9%) from other skin diseases. The Serbian translation of Skindex-29 showed good internal consistency: Cronbach's alpha for Emotional, Symptoms, and Functioning domains was 0.885, 0.752, and 0.901, respectively. Validity of the instrument in all aspects (criterion, content, and construct validity) was satisfactory, yet the Symptoms domain could not discriminate well between more and less severe skin diseases. The Serbian translation of Skindex-29 appears to be a reliable and valid specific instrument for measuring the adverse influence of skin diseases on quality of life.

Uvod. Poremecaji funkcije desnog srca su prediktori lose prognoze kod pacijenata na programu hronicne hemodijalize (HD). U ovoj studiji ispitivana je validnost ehokardiografije u procjeni sistolne i dijastolne funkcije desne komore kod pacijenata na HD. Metode. Istraživanjem je obuhvaceno 30 pacijenata (55±11 godina) na hronicnoj HD kojima su rađene standardna 2D ehokardiografija i tkivni Doppler, prije i nakon HD. Rezultati. Ispitivanje sistolne funkcije desne komore prije i poslije HD je pokazalo da su frakciona promjena povrsine – FAC (36%±11 vs. 34%±11, p=0,464) i amplituda sistolne pokretljivosti anulusa trikuspidne valuvle –TAPSE (25,2mm±4,8 vs. 24,2mm±5, p=0,207) bile u granicama normalnih vrijednosti, nezavisno od smanjenja ukupnog volumena krvi nakon HD, dok je frakciono skracenje – Fs (43,8%±11,6 vs. 39,3%±13,2, p=0,014) bilo znacajno manje nakon HD, sto pokazuje zavisnost ovog parametra od smanjenja cirkulatornog volumena. Tei indeks desne komore pokazao je normalne vrijednosti, nezavisno od smanjenja punjenja desne komore nakon HD (0,59±0,44 vs. 0,69±0,27, p=0,18). Evaluacija dijastolne funkcije desne komore preko brzina transtrikuspidnog protoka (E talas, E/A) pokazala je znacajno smanjenje brzina nakon smanjenja volumena poslije HD, dok je odnos brzina E/E’ (6,02±3,19 vs. 5,66±1,83, p=0,599) ostao u granicama normalnih vrijednosti i nakon HD. Zakljucak. Ehokardiografska procjena sistolne funkcije desne komore pomocu FAC i TAPSE, kao i procjena globalne funkcije miokarda pomocu Tei indeksa, su pouzdane metode kod pacijenata na HD, posto se njihove vrijednosti nisu mijenjale u uslovima smanjenja cirkulatornog volumena nakon HD. Kao pouzdan parametar za procjenu dijastolne funkcije kod pacijenata na HD se može koristiti odnos brzina E/E’, koji se u ovom istraživanju nije znacajno mijenjao usljed smanjenja volumena krvi nakon HD.

Introduction.The aim of the study was to find out the determinants of the quality of life in primary health care patients with type 2 diabetes. Methods. The cross-sectional study included 181 patients, aged 37 to 89 years, with diabetes mellitus type 2, registered with four family medicine practices. The assessment of health status was conducted using medical history, objective examination, laboratory analyses, dilated eye exam, screening for distal symmetric neuropathy and ankle-brachial index measurement. In evaluating the impact of diabetes mellitus on patients’ health status, a generic instrument, the self-administered WHOQOL-BREF questionnaire, was used. Multivariate linear regression models were used to analyze the variables associated with the quality of life. Results. Out of 181 adult patients with type 2 diabetes mellitus, 73 (40.3%) had diabetes for less than 5 years. The mean glycated hemoglobin (A1C) was 7.55% and the mean serum levels of fasting glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were above the recommended values. Most of the patients had comorbidities, chronic diabetes complications and used oral hypoglycemic agents in combination with insulin. The multivariate regression analysis showed that the age, psychological health, nephropathy and environment were associated with the domain of physical health. The determinants of psychological health were age, marital status and environment. Older and single patients had lower scores, whereas those with a better living environment had higher scores in the domain of social relationship. The levels of glycemic control and gender have not been shown to be significant determinants of any of the four domains. Conclusion. The factors associated with the different domains of quality of life in patients with type 2 diabetes are multiple, but mainly relate to age, living environment and diabetes complications. The results can be used as a guideline for defining measures that can improve the quality of life of patients with type 2 diabetes