Background: Neck circumference (NC) is an index of subcutaneous adipose tissue distribution in an area of the upper part of the body. The aim of this study was to assess whether NC can be used as an indicator of central obesity and to determine the prevalence of central obesity in apparently healthy Bosnian young adults. Methods: Participants for this cross-sectional study were recruited using the snowball method. NC was measured in horizontal straight position by placing the top edge of a plastic tape only below the laryngeal prominence and perpendicular to the longitudinal axis of the neck, with the head positioned in the Frankfort horizontal plane. Body mass index, waist circumference (WC), and waist-to-hip ratio were taken following the WHO guidelines. Results: The study included 111 second year University of Sarajevo Dentistry students (49 students of male gender and 62 students of the female gender). Determined the optimal cutoff value of NC in the detection of central obesity based on WC values in healthy young participants of male gender was ≥37.45 cm (P < 0.001), while in healthy young participants of the female gender, it was ≥32.75 cm (P < 0.001). Based on the WHO guidelines for WC, central obesity was determined in 24.49% (n = 12) of male patients, and in 29.03% (n = 18) of female participants included in our investigation (P < 0.05). Conclusions: The results of the present study indicate that NC may be used as a screening tool for central obesity in healthy young adults. Prevalence of central obesity observed among student population suggests that there is a justified need for an implementation of healthy lifestyle programs in this population that would have preventive purposes.

We investigate the nonautonomous difference equation with real initial conditions and coefficients g i , i = 0 , 1 which are in general functions of n and/or the state variables x n , x n − 1 , … , and satisfy g 0 + g 1 = 1 . We also obtain some global results about the behavior of solutions of the nonautonomous non-homogeneous difference equation where g i , i = 0 , 1 , 2 are functions of n and/or the state variables x n , x n − 1 , … , with g 0 + g 1 = 1 . Our results are based on the explicit formulas for solutions. We illustrate our results by numerous examples.

Abstract. Knowing the location of large-scale turbulent eddies during catastrophic flooding events improves predictions of erosive scour. The erosion damage to the Oroville Dam flood control spillway in early 2017 is an example of the erosive power of turbulent flow. During this event, a defect in the simple concrete channel quickly eroded into a 47 m deep chasm. Erosion by turbulent flow is difficult to evaluate in real time, but near-channel seismic monitoring provides a tool to evaluate flow dynamics from a safe distance. Previous studies have had limited ability to identify source location or the type of surface wave (i.e., Love or Rayleigh wave) excited by different river processes. Here we use a single three-component seismometer method (frequency-dependent polarization analysis) to characterize the dominant seismic source location and seismic surface waves produced by the Oroville Dam flood control spillway, using the abrupt change in spillway geometry as a natural experiment. We find that the scaling exponent between seismic power and release discharge is greater following damage to the spillway, suggesting additional sources of turbulent energy dissipation excite more seismic energy. The mean azimuth in the 5–10 Hz frequency band was used to resolve the location of spillway damage. Observed polarization attributes deviate from those expected for a Rayleigh wave, though numerical modeling indicates these deviations may be explained by propagation up the uneven hillside topography. Our results suggest frequency-dependent polarization analysis is a promising approach for locating areas of increased flow turbulence. This method could be applied to other erosion problems near engineered structures as well as to understanding energy dissipation, erosion, and channel morphology development in natural rivers, particularly at high discharges.

Software Defined Networks (SDN) isolate the control plane from the data plane, allowing a global view of the network and providing a high level programmable network. This can be very useful for managing network access control by associating device flows to user profiles. This paper proposes a tool for managing user profiles by authorizing device flows using software-defined networks. This tool has been implemented on the OpenFlow controller POX. In this paper we describe the experiments performed and the results obtained, which show the efficacy and the ease of use of the mechanism.

Ongoing cancer evolution gives rise to intra-tumour heterogeneity (ITH), which is a major mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin and drivers of ITH across cancer types are poorly understood. Here, we extensively characterise ITH across 2,778 cancer whole genome sequences from 36 cancer types. We demonstrate that nearly all tumours (94.7%) with sufficient sequencing depth contain evidence of recent subclonal expansions, and that most cancer types show clear signs of positive selection in both clonal and subclonal protein coding variants. We find distinctive subclonal patterns of driver gene mutations, fusions, structural variation and copy-number alterations across cancer types. Dynamic, tumour type-specific changes of mutational processes between subclonal expansions shape differences between clonal and subclonal events. Our results underline the importance of ITH and its drivers in tumour evolution, and provide an unprecedented pan-cancer resource of extensively annotated subclonal events, laying a foundation for future cancer genomic studies.

Spontaneous spleen rupture rarely occurs, and is primarily present in patients with splenomegaly. This is a life-threatening condition that, without adequate surgical treatment, always ends lethally. The very etiology of spontaneous atriumatic spleen rupture is not known, but it can often be associated with neoplastic diseases, liver cirrhosis, and some infectious diseases. Diagnosis is made by non-invasive methods (findings of red blood cell elements, ultrasonography, computerized tomography of abdominal CT, magnetic resonance NMR). The therapy consists of laparotomy, evacuation of the haemorrhagic content and removal of the spleen. Surgical treatment is successful, and as a postoperative complication, bleeding may occur as a result of inadequate care of the laryngeal artery and vein, and short gastric blood vessels. Here we presented a 58- year- old male patient who, due to a marked abdominal pain, low blood pressure, and low blood cell counts, was taken to hospital and successfully surgically treated at the Clinic for General and Abdominal Surgery.

Rare diseases ('orphan diseases') (RDs) count for 5000-8000 diseases with low prevalence and most commonly of genetic origin. Although most of rare diseases are manifested in early childhood, many are diagnosed in adults, even in elderly. Common characteristics, such as severity, debilitating and life-threatening features, with the lack of a specific drugs, make the treatment of RD a significant public-health problem. Even though randomized controlled trials (RCTs) are the most ideal design for evaluating new drugs, the aim of this review was to present the aggravating circumstances that development of so-called orphan drugs faces in context of RD. We searched the PubMed/Medline for publications on studies and ethics in RDs and applying of 'omics' technologies in analysing tissue samples at biobanks published between 2010 and 2017. In this review, we presented the most significant obstacles in conducting clinical trials in RD as well as main alternative clinical trial designs aiming to decrease the number of patients recruited with increased access to innovative medicines as many as possible. Furthermore, we have presented the possibility of accessing innovative drugs outside of clinical trials as well as ethics violations by the involvement of the subject in clinical trial. Modern technologies in molecular biology will enable the development of 'precision medicine' aimed at identifying the best therapeutic goal, depending on the genetic and epigenetic factors in the affected person. That is why RD biobanks have great significance in the preservation and distribution of tissue samples, in the research of diagnostic biomarkers and the drug development.