<p style="text-align: justify;">Higher level of finalization of new product and production of furniture presents the challenge for all manufacturers of wood. Production of massive wood furniture becomes dominant and presents extraordinary chance for wood product manufacturing industry in B&H. Being introduced with the process capability of the certain company and certain processes, which preceded by built prototype-samples, is of crucial importance for successful agreement and further business cooperation with customers. The aim of this paper work is to determine the most influencing factors on the capability of technological process and to make ranking of criteria influencing on stability and to compare them with factors that have influence on the speed of new product development and to determine correlation between them.<br />Research, carried out in this work, gave the result on estimation of technological capability, done with the company management, including the research related to the speed and development of new product development looking at the same time characteristic spots for improvement of quality management. Results of this research will be the starting point for defining relations between technological capability and the speed of new product development and their relations will be examined throughout χ2 test which<br />will be confirmed throughout the contingency test and Spearman's rank correlation coefficient.</p>
Phthalates are ubiquitous in indoor environments, which raises concern about their endocrine-disrupting properties. However, studies of human uptake from airborne exposure are limited. We studied the inhalation uptake and dermal uptake by air-to-skin transfer with clean clothing as a barrier of two deuterium-labeled airborne phthalates: particle-phase D4-DEHP (di(2-ethylhexyl)phthalate) and gas-phase D4-DEP (diethyl phthalate). Sixteen participants, wearing trousers and long-sleeved shirts, were under controlled conditions exposed to airborne phthalates in four exposure scenarios: dermal uptake alone and combined inhalation + dermal uptake of both phthalates. The results showed an average uptake of D4-DEHP by inhalation of 0.0014 ± 0.00088 (μg kg-1 bw)/(μg m-3)/h. No dermal uptake of D4-DEHP was observed during the 3 h exposure with clean clothing. The deposited dose of D4-DEHP accounted for 26% of the total inhaled D4-DEHP mass. For D4-DEP, the average uptake by inhalation + dermal was 0.0067 ± 0.0045 and 0.00073 ± 0.00051 (μg kg-1 bw)/(μg m-3)/h for dermal uptake. Urinary excretion factors of metabolites after inhalation were estimated to 0.69 for D4-DEHP and 0.50 for D4-DEP. Under the described settings, the main uptake of both phthalates was through inhalation. The results demonstrate the differences in uptake of gas and particles and highlight the importance of considering the deposited dose in particle uptake studies.
Resistive switching (RS) is an interesting property shown by some materials systems that, especially during the last decade, has gained a lot of interest for the fabrication of electronic devices, with electronic nonvolatile memories being those that have received the most attention. The presence and quality of the RS phenomenon in a materials system can be studied using different prototype cells, performing different experiments, displaying different figures of merit, and developing different computational analyses. Therefore, the real usefulness and impact of the findings presented in each study for the RS technology will be also different. This manuscript describes the most recommendable methodologies for the fabrication, characterization, and simulation of RS devices, as well as the proper methods to display the data obtained. The idea is to help the scientific community to evaluate the real usefulness and impact of an RS study for the development of RS technology.
ABSTRACT Introduction: Helicobacter pylori infection results in chronic gastritis, peptic ulcer, or gastric cancer; therefore, eradication of this bacterium is essential. The strategy for developing effective vaccines against H. pylori entails immunization of mice with a combination of classical and recombinant H. pylori antigens, but this has proven to be onerous in all cases. Areas covered: We have reviewed literature databases in PubMed and Scopus using the key words H. pylori, vaccine, and vaccination and have conducted a systematic review of published clinical trials and animal model studies on vaccines against H. pylori and have tried to summarize why the vaccines are not effective or only partially effective. Expert commentary: This is the perfect time to review vaccine development against H. pylori as, after several failed attempts, promising results were reported by Zeng et al. in 2015. Successful vaccine development requires knowledge of both the immune mechanisms active during natural infection by H. pylori, owing to the complicated host response against the pathogen, and the factors that allow the persistence of bacteria, such as genetic diversity of H. pylori. Moreover, various clinical trials are needed to prove vaccine efficacy.
The success of any business depends fundamentally on the possibility of balancing (symmetry) needs and their satisfaction, that is, the ability to properly define a set of success indicators. It is necessary to continuously monitor and measure the indicators that have the greatest impact on the achievement of previously set goals. Regarding transportation companies, the rationalization of transportation activities and processes plays an important role in ensuring business efficiency. Therefore, in this paper, a model for evaluating performance indicators has been developed and implemented in three different countries: Bosnia and Herzegovina, Libya and Serbia. The model consists of five phases, of which the greatest contribution is the development of a novel rough additive ratio assessment (ARAS) approach for evaluating measured performance indicators in transportation companies. The evaluation was carried out in the territories of the aforementioned countries in a total of nine companies that were evaluated on the basis of 20 performance indicators. The results obtained were verified throughout a three-phase procedure of a sensitivity analysis. The significance of the performance indicators was simulated throughout the formation of 10 scenarios in the sensitivity analysis. In addition, the following approaches were applied: rough WASPAS (weighted aggregated sum product assessment), rough SAW (simple additive weighting), rough MABAC (multi-attributive border approximation area comparison) and rough EDAS (evaluation based on distance from average solution), which showed high correlation of ranks by applying Spearman's correlation coefficient (SCC).
Abstract Trigeminal neuralgia is a chronic pain disorder affecting the face. In approximately 80% of cases, it is most commonly caused, when the root entry zone (REZ) of the trigeminal nerve is compressed by the superior cerebellar artery (SCA). The etiology of the remaining 20% of cases is distributed among venous, arteriovenous malformations, posterior fossa tumors, multiple sclerosis plaque compressions, and other pathologies. Combinations of those compressive factors are very rare.1 2 3 4 Herein, we present a video clip of microvascular decompression (MVD) in a 73-year-old female, who has failed conservative treatment with 6 medications over 10 years. She was affected by a unique triple compression of the right REZ by the SCA, anterior inferior cerebellar artery (AICA), and petrosal vein complex (Fig. 1A). Right-sided microsurgical decompression of the REZ of the trigeminal nerve through standard retrosigmoid craniotomy was performed by the senior author (K.I.A.). The SCA and AICA were separated from the nerve using Teflon pledgets. The petrosal vein complex was coagulated and divided, freeing up the right trigeminal nerve (Fig. 1B). The patient was discharged home on the third postoperative day with complete resolution of trigeminal neuralgia. The link to the Video can be found at: https://youtu.be/PYVvImGW0yE.
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