A term systems of systems (SoS) refers to a setup in which a number of independent systems collaborate to create a value that each of them is unable to achieve independently. Complexity of a SoS structure is higher compared to its constitute systems that brings challenges in analyzing its critical properties such as security. An SoS can be seen as a set of connected systems or services that needs to be adequately protected. Communication between such systems or services can be considered as a service itself, and it is the paramount for establishment of a SoS as it enables connections, dependencies, and a cooperation. Given that reliable and predictable communication contributes directly to a correct functioning of an SoS, communication as a service is one of the main assets to consider. Protecting it from malicious adversaries should be one of the highest priorities within SoS design and operation. This study aims to investigate the attack propagation problem in terms of service-guarantees through the decomposition into sub-services enriched with preconditions and postconditions at the service levels. Such analysis is required as a prerequisite for an efficient SoS risk assessment at the design stage of the SoS development life cycle to protect it from possibly high impact attacks capable of affecting safety of systems and humans using the system.

Real-time adaptive systems are complex systems capable to adapt their behavior to changing conditions in the environment, and/or internal state changes. Highly dynamic and possibly unpredictable environments, and uncertain operating conditions call for new paradigms of software design, and run-time adaptation mechanisms, to overcome the lack of knowledge at design time. Main application areas include vehicles or robots that need to collaborate to achieve a common task, e.g., minimize fuel consumption, moving objects at a construction site, or performing a set of operations in a factory. Moreover, these vehicles or robots need to interact and possibly collaborate with humans in a safe way, e.g., avoiding accidents or collisions, and prevent hazardous situations that may harm humans and/or machines. % This paper proposes a framework for developing safe and secure adaptive collaborative systems, with run-time guarantees. To enable this, our focus is on requirement engineering and safety assurance techniques to capture the specific safety and security properties for the collaborative system, and to provide an assurance case guaranteeing that the system is sufficiently safe. Moreover, the paper proposes an architecture and behavioral models to analyze the requirements at run-time. Finally, we design a suitable deployment platform to perform the run-time analysis and planning while guaranteeing the real-time constraints.

Poor adherence to medical recommendations is a well-recognized catalyst for public health consequences worldwide. The literature highlights health consciousness as a likely antecedent to patient–physician trust, which in turn promotes medical adherence. Nevertheless, principles of patient-centered care suggest that patient perceptions of their doctor’s appraisal of their emotions may influence the path between trust and medical adherence. Accordingly, this study tested the mediating role of patient–physician trust in the relation between health consciousness and medical adherence and assessed whether patient ratings of their doctor’s appraisal of their own and their patients’ emotions moderated the mediated relation. Data were collected via self-report questionnaires from two culturally and economically diverse countries: Bosnia-Herzegovina (N = 262) and the United States (N = 314). Participants were young, healthy adults who visited their primary care physician in the past year. The study employed confirmatory factor analysis, mediation, and moderated mediation analyses. The results indicate that health consciousness positively related to patient–physician trust, which was in turn related to higher medical adherence and which mediated 28% of the total effect of health consciousness. Nevertheless, among patients who rated their physicians to have low appraisal for their patients’ emotions but high appraisal for their own emotions, the path from trust to adherence was not significant. These results highlight the importance of promoting health consciousness among young individuals, all while training practitioners to be attuned to their patients’ emotions and circumstances above their own. However, additional findings indicate that the interrelation between doctors’ emotional attributes and adherence is not necessarily one directional and warrants further investigation.

BACKGROUND Clinical Chemistry is the backbone of medical treatment, diagnostics, and prevention. The laborato-ries are trying to improve the quality and to reduce diagnostic errors and processing time and safeguard trace-ability of all laboratory procedures to ensure patient safety. Six sigma belongs to statistical quality control and provides a new methodology for measuring and improving process performance in laboratory. METHODS Activities of AST, ALT, CK, LDH, Amy, and γ-GT were determined by standard kinetic methods on a Vitros 5600 biochemistry analyzer. Two daily quality controls (Verifier I and Verifier II) were run over 60 days. Total percent CV was calculated from routine daily QC. Between-instrument bias was also calculated from daily QC. RESULTS The calculated sigma metrics for AST were 6.9 and 3.8; for ALT 9.3 and 5.6; for CK 6.6 and 5.3; LDH 5.2 and 5.2; for γ-GT 4.9 and 2.7; and for amylase 8.7 and 7.1. Analytical performance for AST, ALT, CK, LDH, and Amylase is world class. On the other hand, γ-GT analytical performance is poor. CONCLUSIONS Six Sigma benefits from earlier quality management approaches that creates new challenges for medical laboratories.

Outlier detection represents the problem of finding patterns in data that does not fit in expected behaviour. In this paper, outlier detection is done over real transactional data set of the distribution company. Outlier detection is done over time-series data, and over an ordered number of products that can be found within transactions. Unsupervised techniques and methods, S-H-ESD and LOF, are applied because data set is unlabelled. Implementation is performed in R language, and web application dashboard using R Shiny is made. Based on collected results, a proposal for creating the outlier detection and prevention system is made, and ideas for further improvements and additional analysis are given.

The identification of association rules is the problem of finding associations between different items in the same transactions. In this paper, performance comparison of different variants of Apriori, FP-Growth and ECLAT algorithms was performed over the real transactional data set of the distribution company by using R programming language and its appropriate packages, and the results obtained are later on explained. Then, the identification and visualization of the association rules of the said real data set was performed.

Objective. Childhood-onset systemic lupus erythematosus (cSLE) is usually a more severe and aggressive disease than adult-onset SLE (aSLE), but cellular and subcellular reasons for these differences are not well understood. The present study analyzed Th subsets, STAT1/STAT5 signaling response, and cytokine profiles of cSLE. Methods. FOXP3+ regulatory (Treg) and effector Th subsets, expression and phosphorylation of STAT1/STAT5 in Th, and cytokine profiles were measured in the peripheral blood of patients with cSLE and healthy controls (HC), using flow cytometry and immunoassay on a biochip. Results. Significant correlation between expression of the activation marker HLA-DR and decreased Th counts, an increase in the percentage of FOXP3+ Th, and a decrease in the activated Treg (aTreg) subset among them were found in cSLE. In contrast to our previous findings in aSLE, no significant differences in percentages and a significant decrease in the numbers of the naive-resting Treg (rTreg) subset compared to HC were found. The percentages of CD25− cells, possibly reflecting interleukin 2 depletion, were significantly increased in cSLE aTreg, but not in the rTreg subset. Consistent with the results of our previous studies in aSLE, increased expression of STAT1, along with significant correlation between decreased Th counts and their increased basal phosphorylation of STAT5, were also found in cSLE. Conclusion. Our results suggest that the key difference in Treg homeostasis between cSLE and aSLE is in the rTreg subset. However, perturbed aTreg homeostasis, increased levels of STAT1 protein, and homeostatic STAT5 signaling appear to be intrinsic characteristics of the disease, present in cSLE and aSLE alike.

OBJECTIVES To provide an overview of the paediatric rheumatology (PR) services in Europe, describe current delivery of care and training, set standards for care, identify unmet needs and inform future specialist service provision. METHODS An online survey was developed and presented to national coordinating centres of the Paediatric Rheumatology International Trials Organisation (PRINTO) (country survey) and to individual PR centres (centre and disease surveys) as a part of the European Union (EU) Single Hub and Access point for paediatric Rheumatology in Europe project. The survey contained components covering the organization of PR care, composition of teams, education, health care and research facilities and assessment of needs. RESULTS Response rates were 29/35 (83%) for country surveys and 164/288 (57%) for centre surveys. Across the EU, approximately one paediatric rheumatologist is available per million population. In all EU member states there is good access to specialist care and medications, although biologic drug availability is worse in Eastern European countries. PR education is widely available for physicians but is insufficient for allied health professionals. The ability to participate in clinical trials is generally high. Important gaps were identified, including lack of standardized clinical guidelines/recommendations and insufficient adolescent transition management planning. CONCLUSION This study provides a comprehensive description of current specialist PR service provision across Europe and did not reveal any major differences between EU member states. Rarity, chronicity and complexity of diseases are major challenges to PR care. Future work should facilitate the development, dissemination and implementation of standards of care, treatment and service recommendations to further improve patient-centred health care across Europe.

The paper presents an approach to web-based visualization of automatically generated data models, which combines visualization principles used in desktop applications, and usage of web-based technologies. The proposed approach is implemented and integrated with an existing online system for automatic synthesis of conceptual database models based on business process models. The approach and implemented online system named AMADEOS are illustrated by an example of visualization of the UML class diagram representing the conceptual database model automatically generated based on the source BPMN model.

Increasing student motivation and engagement in classroom (and during the study in general) is the aim of every lecturer. Never stopping development of new digital tools and media present a new challenge in the educational process. The goal of this research is to increase the knowledge and understanding of the influence of Bring Your Own Device (BYOD) approach (and use of the mobile devices in classrooms in general) on: teachers’ practice and students’ classroom activities, students’ attitude about bringing the mobile phones in the class and mobile phone applications in education processes. This research focuses on undergraduate and postgraduate mechanical engineering students. Personal reflection of the lecturers and online survey for students was used as a tool to investigate participants’ attitude towards mobile applications as a method of promotion of active learning in engineering education.

This paper presents a new approach for solving decentralized bi-level multi-objective linear fractional programming problems. The main goal was to find a simple algorithm with high confidence of decision-makers in the results. First, all the linear fractional programming models on the given set of constraints were solved separately. Next, all the linear fractional objective functions were linearized, membership functions of objective functions and decision variables controlled by decision-makers at the highest level calculated, and a fuzzy multi-objective linear programming model formed and solved as linear goal programming problem by using simplex algorithm. The efficiency of the proposed algorithm was investigated using an economic example, and the obtained results compared with those obtained using an existing method.

The 16 articles in this special section examine both licensed and unlicensed spectrum for 5G/B5G wireless networks. The incredible increase in connected appliances and downloaded applications has pushed mobile operators to the limits of their licensed spectrum bands. This has triggered the idea of evolving the current radio access network to use the underutilized unlicensed spectrum to extend spectrum resources beyond current usage charts. This mode of cellular access has raised a lot of questions about use cases, enabling technologies, and fairness to other native unlicensed users, such as WiFi. Nevertheless, unlicensed access is being accepted as one of the most significant solutions to improve the resource availability and system scalability in future fifth generation (5G)/beyond 5G (B5G) networks.

This paper presents an educational game fostering a new experience-based approach to teaching knowledge transfer using a codification strategy alone. The goal is to address and highlight some common issues and challenges that occur during knowledge transfer in product development and that are often difficult for especially students to grasp through exclusively a theoretical teaching approach. The game is introduced to 60 students in the final year of their Master's curriculum. In parallel, the game has been applied in a similar setting in a comparable higher educational institution, as well as in a product development organization.“Sometimes you win—other times you lose and learn.”