Histamine is a biologically active amine (biogenic amine) that has a broad spectra of physiologic and pathologic reactions in the organism. Its effects are shown through 4 types of specific receptors (H1, H2, H3 and H4). Histamine is one of the main causes of intestine disorders and the occurrence of diarrhea, both of which are very common in broilers. Whilst there is no information in scientific literature about the presence of histaminic receptors in smooth muscles of the small intestine wall of broilers (duodenum, jejunum and ileum), we tried to determine their presence, distribution and type in this kind of muscles. Investigations were carried out on isolated smooth muscles of the circular and longitudinal layer of the broiler small intestine (strip dimension 3-4 mm x 2 cm). The muscle strip was then placed in an isolated organ bath and the contractions obtained were registered with isometric transducers on a two-channel printer. This was done following the addition of histamine, betahistine (H1 agonist), and mepiramine (H1 antagonist). Muscle vitality was checked by adding acethylcholine chloride. Using the obtained results, it can be concluded that H1 types of histaminergic receptors are present in smooth muscles of the small intestine of broilers. .

1 Ahmed Smajlović, MSc, senior assistant; Asima Baković, DVM, expert assistant; Indira Mujezinović, assistant professor; Mehmed Muminović, DSc, full professor; Department for Pharmacology and Toxicology, Veterinary faculty, University of Sarajevo, Zmaja od Bosne 90, 71000 Sarajevo 2 Muhamed Smajlović, DSc, assistant professor, Department of Food Hygiene and Technology, Veterinary faculty, University of Sarajevo, Zmaja od Bosne 90, 71000 Sarajevo 3 Osman Kapetanović, DM; Senada Hadžijusufović, DM; Sanitary Inspection, Ministry of health, canton Sarajevo, Bulevar Meše Selimovića 12, 71000 Sarajevo IDENTIFICATION OF HISTAMINE CONTENT IN FISH SAMpLES

1 Mr. sc. Ahmed Smajlović dr. vet. med., viši asistent; Asima Baković dr. vet. med., stručni suradnik; dr. sc. Indira Mujezinović, docent; dr. sc. Mehmed Muminović, redovni profesor, Katedra za farmakologiju i toksikologiju, Veterinarski fakultet Univerziteta u Sarajevu, Zmaja od Bosne 90, 71000 Sarajevo 2 Dr. sc. Muhamed Smajlović, docent, Zavod za higijenu i tehnologiju živežnih namirnica animalnog porijekla, Veterinarski fakultet Univerziteta u Sarajevu, Zmaja od Bosne 90, 71000 Sarajevo 3 Osman Kapetanović dr. med.; Senada Hadžijusufović dr. med., Sanitarna inspekcija, Ministarstvo zdravstva Kantona Sarajevo, Bulevar Meše Selimovića 12, 71000 Sarajevo UTVRĐIVANJE PRISUSTVA HISTAMINA U UZORcIMA RIbE

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