Multiple sclerosis is a chronic demyelinating disease of the central nervous system, that causes permanent disabilities. Diagnostics of this disease by magnetic resonance requires the appliance of corresponding protocols with the sequences that emphasize demyelinating plaques. Standard sequences T1 and T2 sometimes cannot clearly show demyelinating plaques, and it is necessary to work on perfecting the sequences that emphasize the changes in the brain formed as demyelinating plaques. The aim of the survey: The aim of the survey was to estimate the value of MR sequence with double inversion recovery (DIR) in discovering demyelinating lesions of the brain in multiple sclerosis (MS). Patients and methods of the survey: 22 patients were included in the survey, they were of both genders and different age. The patients were with diagnosed with multiple sclerosis. The patients underwent the scanning on MR apparatus 1.5 T. Comparison of DIR sequence to FLAIR and T2 W sequences were done. Result: DIR sequence proved significantly more MS lesions compared to T2W or FLAIR sequence, including intracortical, juxtacortical and paraventricular zone of the brain. In the infratentorial zone of brain, T2W sequence proved significantly more plaques compared to DIR and FLAIR. Conclusion: DIR sequence compared to T2W and FLAIR sequences discovered more demyelinating lesions in targeted regions that were examined. DIR sequence is a tool that contributes to easier and faster diagnostics of multiple sclerosis, needs to be included into the routine MR protocol of patients with MS, in order to discover more easily intracortical and juxtacortical MS lesions of the brain.

Aim To demonstrate the effects of early diagnosis of overuse syndrome in the wrist on healing, pain intensity and quick recovery to daily work and sport activities. Methods This clinical retrospective study included 60 patients of both sexes aged from 22 to 44 years, with pain in the wrist and clinical signs of creeping tenosynovitis. Patients were divided into two groups: the first group - persons doing sports activity, and the second group - patients who did not deal with sports activities. Results Females in 31 (51.7%) cases compared to males with 29 (48.3%) were slightly more represented in the total sample. Patients with injuries due to sports activities had previously reported to the physician and the diagnosis was set at an average of 3.1±0.9 days after the first symptoms (the range of 2-5 days), compared to the patients of the second group whose diagnosis was set at an average of 4.7±1.1 days after the first symptoms (p<0.05). Conclusion Patients involved in sports activities were more motivated for faster recovery, they had earlier doctor's examination with rapid reduction of subjective symptoms during intensive physical therapy.

Objective: To investigate possible prognostic values of CD4+, CD8+ T-lymphocytes, CD4/CD8 ratio to clinical course of chickenpox in immunocompetent hosts. Materials and methods: We performed a prospective study which included 69 immunocompetent patients with chickenpox who were addmited to Clinic for infectious disease, Clinical Center University of Sarajevo, in a 18 month period. All patients were divided into two groups depending on clinical presentation on admission. Patients with mild clinical form were dedicated to „outpatient” group, and patients with moderate, severe or life-threatening clinical forms were dedicated to „hospitalized” group. Also 30 healthy volunteers are included in study as a control group. We analyzed values of CD4+, CD8+ percentage, CD4/CD8 ratio with comparison to clinical course of chickenpox. All specimens were taken in acute phase of illness. Results: Values of CD4+ percentage were significantly declined in a group of hospitalized patients, compared to group of outpatients and control group. Values of CD8+ percentage were higher in a group of hospitalized patients, while CD4/CD8 values were lower in comparison to a group of outpatients and control group. Conclusion: We found significant correlation between these parameters and clinical course of chickenpox.

Introduction: In the late 70s of the last century, the mortality rate due to polytrauma amounted to 40%. This led to a new approach to this patient category with the goal of improving the treatment outcome.  According to the German trauma register, the rate of mortality in polytrauma at the end of the last century was 18.6%. The goal of this study is to determine the incidence of hospital mortality in polytrauma patients in a tertiary institution in Bosnia and Herzegovina.Methods: We analyzed patient medical records from the Intensive Care Unit of the Clinic of Orthopedics and Traumatology at University Clinical Center Sarajevo, from January 1, 2012 to December 31, 2012.Results:  There were 70 polytrauma patients in 2012, with average age 47.55 (range 8-77) years. Half of the patients were younger than 50 years. Age groups most frequently affected were 61 and older (25.7%), 51-60 years (24.3%), and 31-40 years (21.4%). Lethal outcome occurred in 10 patients (14.3%), while 60 patients (85.7%) survived and were treated until discharge or transfer to a different department.  The average Injury Severity Score (ISS) in patients with lethal outcome was 71.50, while in survivors was 37.  The largest percentage of lethal outcomes was recorded in cases of traffic accidents.Conclusion: The mortality rate among hospitalized polytrauma patients in the tertiary institution in Bosnia and Herzegovina is similar to reported mortality rates in other countries with developed healthcare system.

Introduction