Normal 0 21 false false false BS-LATN-BA X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; line-height:150%; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman",serif; mso-ansi-language:BS-LATN-BA; mso-fareast-language:EN-US;} The aim of this study was to determine the levels of cadmium in cattle meat and offal on the area of Central Bosnia Canton and to estimate the level of population exposure to cadmium through consumption of cattle meat and offal. Fifty samples were analysed using inductively coupled plasma mass spectrometry, out of which twenty samples of kidney tissue, twenty samples of liver tissue and ten samples of muscle tissue. Determined cadmium levels in cattle kidney varied between 0.088 and 4.493 mg/kg, while cadmium levels in liver were determined in the range from 0.016 to 0.206 mg/kg. The mean value of cadmium in kidney was 0.750 mg/kg, while the mean value of cadmium in liver was 0.076 mg/kg. Cadmium levels in muscle tissue were less than 0.008 mg/kg in all analysed samples. In three samples of kidney (15% of the analysed) cadmium levels exceeded maximum permitted level, while no such case was found for liver and muscle tissue. Estimated weekly intake of cadmium due to the consumption of cattle meat is 1.74 x 10 -3 m g/kg body weight. Weekly intake of cadmium by consuming cattle kidney is 9.08 x 10 -3 m g/kg body weight, whereas weekly intake of cadmium via cattle liver is 1.23 x 10 -3 m g/kg body weight. The intake of cadmium due to the consumption of cattle meat and offal in the examined population is within the tolerable weekly intake. Exposure to cadmium from cattle meat in the examined population does not pose a risk for health.
: Schinus terebinthifolius Raddi is a plant species belonging to Anacardiaceae family, native to South America, with particular abundance in Brazil, Argentina and Paraguay. It is commonly known as Brazilian pepper tree. All plant parts have been used in traditional medicine for the treatment of several pathologies. In this paper, the cytotoxic effects of the essential oil of the commercial pink pepper fruit from the Tuzla market were investigated. To assess the cytotoxic potential, a tetrazolium salt reduction (MTT) viability assay was performed. The experiments were carried out on 3 human cell lines: lung carcinoma (H460), cervical adenocarcinoma (HeLa) and colorectal carcinoma (HCT116). Using GC/MS, 24 components of red pepper essential oil were identified, of which α-pinene, α-phellandrene, δ-3-carene and D-limonene dominate. The essential oil of the pink pepper fruit showed cytotoxic activity in the case of all tested cell lines under in vitro conditions.
: Hyperpigmentation is a skin disorder caused by increased melanin production. It appears in the form of dark spots and makes the complexion uneven. Pigmentation spots, such as age spots (also known as sun spots), manifest themselves most often on the palms, face and hands. The aim of this work was to investigate and evaluate which of the active substances used in hyperpigmentation treatments has the highest degree of tyrosinase inhibition, and the best antioxidant and antimicrobial activity. Kojic acid, niacinamide and grapevine extract were used as active substances in the formulations. When summarizing the results, kojic acid gave the best results, followed by niacinamide, and finally grapevine extract. However, it is necessary to perform a long-term in vivo study on volunteers that will show the effectiveness and efficiency of the mentioned substances. In addition to the treatment of hyperpigmentation, the mentioned substances can also be used in antiaging skin treatments due to the presence of antioxidant activity.
: Speedwells ( Veronica officinalis L.) is a plant species used in traditional medicine for the preparation of teas, tinctures and other preparations for the treatment of diseases of the skin, respiratory and digestive organs. In this paper, the biological activity of the methanolic extract of the speedwells was examined. To assess the cytotoxic potential, a tetrazolium salt reduction (MTT) viability assay was performed. The experiments were carried out on 3 human cell lines: lung carcinoma (H460), cervical adenocarcinoma (HeLa) and colorectal carcinoma (HCT116). Antimicrobial potential was tested using the diffusion technique on three bacterial strains: S. aureus , E. faecalis and S. enterica . Inhibition of free radicals was tested using the ABTS and DPPH methods, and the reduction potential of the extract of the speedwells was confirmed by the FRAP method. The treatment of HeLa, H460, and HCT116 cell lines with the methanolic extract of speedwells demonstrated a dose-dependent decrease in cell growth. The extract showed a high inhibition of the growth of S. aureus but also a complete absence of activity in the case of E. faecalis . A high efficiency of inhibition of DPPH and ABTS radicals, as well as reducing ability, was recorded.
: Sebum is an oily liquid produced by the sebaceous glands. It serves as a protective barrier for the skin, keeping it hydrated and enhancing its elasticity. Sebum contains triglycerides, fatty acids, wax esters, antioxidant squalene, and cholesterol. While the highest concentration of sebum is produced on the face, it is also present on other parts of the skin, including the scalp. Excessive sebum secretion leads to oily skin, but even dry and normal skin types produce a certain amount of sebum. Cleansing foams and tonics for oily skin have an advantage over other pharmaceutical products, such as creams, soaps, and liquid powders, as they can be applied to all areas of the skin. Niacinamide (C 6 H 6 N 2 O) is a pyridinecarboxyamide and organic molecule belonging to the vitamin B group. In recent years, niacinamide has become widely used in cosmetology for the formulation of various pharmaceutical products, primarily for dermal application. However, it is also incorporated into shampoos and hair tonics. Niacinamide is effective in reducing sebum levels on the skin, providing hydration, strengthening the skin's protective barrier, and minimizing visible wrinkles. This study explores the effectiveness of niacinamide as an active component in tonics and foams, along with the stability of these formulations, their microbiological purity, and in vivo testing on volunteers. The MPA 6 device, used in skin bioengineering, was employed to measure the amount of sebum on volunteers' facial skin before and after using a cleansing foam for oily skin.
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