Replacement therapy is a treatment that is not based on accepted medical knowledge and science that is not in accordance with current medical doctrine. Additional treatment is not contrary to the accepted doctrine of medical schools, but serves only as a supplement to the accepted treatment. Most general practitioners in England and Germany do not contradict these forms of treatment. On average 2/3 of patients with MS in the course of the disease try alternate options and additional treatment. Alternate forms of treatment that are most commonly used are: diet, homeopathy, chiropractic procedures and methods of relaxation Detrimental eff ects of alternative and complementary treatments for patients with MS is not known, but we must avoid the use of active substances entering the body and blood of patients, because in that way we can start a modifi ed immune response. Used are acupuncture, and particularly yoga. Cannabis takes special place. Cannabinoids have antioxidant and neuroprotective eff ect. Oral cannabinoids and marijuana smoking can relieve some symptoms of MS including spasm and pain. Th e controlled studies did not validate the eff ect of oral cannabinoids on spasm in MS. Th e aim is to give a brief overview of dietary supplements and the eff ects of certain vitamins, minerals and oil in people with multiple sclerosis.

4 th international epilepsy symposium in Pula – how to start seizure treatment Disorders of circulation in the brain caused by a reduced or complete interruption of blood fl ow in certain irrigation area, have resulted in " outage of some function " of the brain, depending on localization of disorder. If that outage lasts for a shorter period of time-up to 1 hour, we are talking about transient ischemic attacks, and if a neurological defi cit lasts longer than an hour, we are talking about stroke with thrombotic or embolic genesis. Stroke is despite diagnostic and therapeutic advances in medicine, the third leading cause of mortality in the world (after cardiovascular and malignant diseases), the second leading cause of disability (after trauma) and also the second leading cause of demen-tia. Previously there was the understanding that stroke is a disease of older age, today is the fact that 46% of stroke patients are aged 45-59 years. Th e leading risk factor for stroke is hypertension followed by smoking, heart disease and cardiac rhythm disturbances, especially atrial fi brillation, followed by diabetes mellitus, dyslipidemia, stress, physical inactivity, obesity, unhealthy diet... Atrial fi brillation with other cardiac rhythm disturbances is the cause for the occurrence of stroke in 20-25% of cases, and is much more common cause of TIA in both the front and rear brain circulation. Th e most frequently cardiac rhythm disturbances are the result of arteriosclerotic change of the heart and blood vessels, but atrial fi brillation can occur in the endo-crine metabolic disorders, mostly hyperthyroidism. At the Neurology Clinic in Sarajevo, we explored the correlation of atrial fi brillation in cases of TIA and ischemic stroke, and came to the conclusion that in cases of ischemic stroke, atrial fi brillation was present as the cause in 20%, and in TIA cases in as many as 27%. CONCLUSION-Atrial fi brillation has a significant place in the etiology of TIA, the anterior and posterior brain circulation, but also of defi nite isch-emic stroke. Duly detection of atrial fi brillation and its treatment it is possible to prevent the occurrence of defi nite stroke, at least in part.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). It is characterized by loss of myelin, the fatty tissue that surrounds and protects nerve fibres allowing them to conduct electrical impulses. Recent data indicate that oxidative stress (OS) plays a major role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to estimate level of serum total antioxidative capacity in patients with multiple sclerosis. Our cross-sectional study included 33 patients with MS and 24 age and sex matched control subjects. All our patients had a Poser criteria for definite diagnostic categories of multiple sclerosis. Serum total antioxidant capacity (TAC) was measured by quantitative colorimetric determination, using Total antioxidant Capacity-QuantiCromAntioxidant Assay Kit (BioAssay systems, USA; DTAC-100). Mean serum TAC in multiple sclerosis group of patients was 119.2 mM Trolox equivalents and was significantly lower (p<0.001) compared to the control group of subjects (167.1 mM Trolox equivalents). Our results showed that oxidative stress plays an important role in pathogenesis of multiple sclerosis. This finding, also, suggests the importance of antioxidants in diet and therapy of MS patients.