Background: The development of medicine and pharmacy in the Bosnia and Herzegovina was marked by different historical periods–first they were settled by the Illyrians and Delmatians, and after them came the Romans, the Ottoman Empire and the Austro-Hungarian Monarchy. Objective: The aims of this article are to show, based on the available literature: a) The development of medicine and pharmacy in Bosnia and Herzegovina from the medieval period until the Second World War; b) The most significant historical events that marked the development of medicine and pharmacy in the areas of Bosnia and Herzegovina; c) Methods of treatment, medicinal forms and preparations that were used in the mentioned period. Methods: The subject of this study was the development of medicine and pharmacy in the areas of Bosnia and Herzegovina from the 14th century until the Second World War. In order to achieve the set goals, a) Retreival of professional and scientific literature and b) Search of scientific databases and web pages on the Internet that offer adequate and relevant data and historical facts related to the subject of studies were carried out. Most of the facts are covered in previously published articles by the author and deposited in the PubMed and PubMed Central databases, as well as in books and monographs by the author of this text. Results and Discussion: In the Middle Ages, folk medicine was present, in which herbalists looked for medicines in certain plant and animal species. In the 13th century, Bosnia was settled by the Franciscans, who permanently marked the development of medicine and pharmacy. They are educated at prestigious universities abroad, from where they bring their knowledge, skills and recipes and write them in books, which are called ljekaruse (medicine books). Every historical period brought some changes for medicine and pharmacy, so the Ottoman Empire brought customs of frequent cleaning, public fountains and hammams were built. During the reign of the Austro-Hungarian Monarchy, the first hospitals and pharmacies were established, and laws on pharmacy activity were introduced. Written documents on the history of the medicine and pharmacy development in Bosnia and Herzegovina are mostly found in the libraries of monasteries, and a significant number of them are also in the libraries of madrasas, and the National and University Librarie in Sarajevo and the library of former Institute of Hygiene in Sarajevo. Conclusion: In connection with the medical and pharmacy practice of the Bosnian Franciscans, the question of the various medical records that they created, which helped them in their health efforts, stands out. First of all, we are talking about numerous medicinal books, so called ”ljekaruse”. On the soil of Bosnia and Herzegovina, there were many such “ljekarusa” who mostly grew up at the sources of national experience. In those books, the recipes are mostly based on the use of medicinal herbs. Historians of medicine believe that these medicinal books represent the cultural and historical significance of our regions.

Background: Cardiovascular diseases (CVD) are the cause of 17 million deaths a year worldwide, of which 25% are sudden cardiac deaths (SCD). In Europe cardiovascular diseases (CVD) remains a leading cause of death in Europe accounting for 3.9 million deaths each year. Even with well-known risk factors and the current standards of health care, improvement of health and quality of life of CVD patients are still remains one of the biggest public health challenges we must overcome. Objective: The aim of this study was to analize of current strategic documents and relevant facts of WHO and other appropriate institutions regarding CVDs prevention and control for potentialy use in Bosnia and Herzegovina (B&H). Methods: Authors made a narrative review to provide a brief overview of the recent and relevant documents of good practice in prevention, diagnostic and therapeutic approaches of cardiovascular diseases that should be consider as milestones for the health authorities in the Federation of B&H. Results and Discussion: Bosnia and Herzegovina is among the countries with a high risk of CVD together with Albania, Croatia, Czech Republic, Estonia, Hungary, Kazakhstan, Poland, Slovakia, and Turkey. The main public health challenge in Bosnia and Herzegovina is reducing noncommunicable diseases (NCDs): heart disease, stroke, cancer, diabetes and chronic respiratory disease. NCDs are estimated to account for 80% of the country’s annual deaths, and addressing them is the foremost public health priority in the country. Cardiovascular diseases still represent a worldwide public health problem, with some new dimensions caused by challenges caused through pandemic of COVID-19. The well-known cardiovascular risk factors require new and more efficient public health approaches to the prevention and control. Conclusion: Due to the recently developed cardiovascular guidelines that were made by the European Society of Cardiology and World Heart Federation, key priority for health authorities should be is to update the existing CVD guidelines in the Federation of BiH in accordance with the international good practice to support healthcare professionals in their efforts to reduce the burden of cardiovascular disease in both individual patients, as well as at a population level..

Background: Medical professionals (doctors and other medical staff) in the field of healthcare everyday must make calculated decisions which have important consequences, impacting patients on the individual level, local (community), national or global level. Healthcare professionals must at times make these choices with limited information, resources, and knowledge, and yet is is expected that these decisions are highly calculated and accurate. It is important to familiarise oneself with the exact definitions regarding medical decision making. Objective: The aim of this study was to describe application of the most important rules to help decision makers to be good or excellent decision makers in medical practice at every level of health care system. Methods: The author used descriptive method of explanation teoretical and practical issues regarding application of od decision making processes in the praxis, based on searchied scientific literature about this topic deposited in online databases. Results and Discussion: The author of this paper discussed about important topics: a) the importance of medical decision in emergency situations; b) the varies of decision making with solving problems by medical professionals; c) the limitations when it comes to medical decison making; and d) what doctors need to follow regarding decision making in the praxis. Two factors that have influenced to the decision process: a) degree of uncertainty about future events; b) usefulness of outcomes in any particular case. The clinical decision problem analysis process demands: a) explicit formalization of a decision making problem or the description of the medical problem decision with a registration of all possible actions which have to be undertaken and registration of all the possible so determined outcomes. b) construction of the decision tree which presents all described actions and outcomes with predictions of the probabilities and the choice of the most optimal action based on the probability outcome and its use. Doing this allows us to delve deeper into more intricate options present within medical decision making. Simple put, a decision is a choice between two options. The person or entity conducting that decision is the decision maker. The exact definition is “Under the decision should imply some specific action which is selected from several variables or which satisfies the expectation that is previously set”.Many different factors and individuals may be involved in medical decision making, with varying consequences, according to different players and settings. Conclusion: A vital component of medical decision making is evaluation. Decision makers must concisely evaluate situations, in order to make better choices. For example, when examining a health care system, their decisions should consider the following questions, such as, what is the health status of the given population? What economic resources are at the disposal of our patients, and government? How effective is the current healthcare model that is already in place? Does the existing social system pay enough attention to the healthcare protection? Does the organisation structure of the healthcare system satisfy? Are the existing practice and the healthcare technologies secure, effective, and suitable? Are the planning, programming, determination and the choice of priority the adequate to the needs of people? How are the monitoring and evaluation of healthcare system quality organised? These are a few examples of evaluation in medical decision making.

This is the issue of third volume of EFMI Inside - the official magazine of the European Federation for Medical Informatics (EFMI), founded in Lyon, France in August 2019, during “MEDINFO 2019” Conference and EFMI Council meeting. In this issue readers can find important information about events organized during 2022 by EFMI Working Groups and national Medical informatics associations, including the most influential Conference - 32nd MIE 2022 Conference held in Nice, France in May 2022, and EFMI STC held in Cardiff in September 22. This EFMI Inside issue contains important facts about other EFMI activities which needed to be recorded for people who couln’t be active participants at the evenings organized by EFMI and members of EFMI associatins.. Very important part of the issue is official report of the EFMI Council Secretary, Professor Alfred Winter about EFMI Council meetings during years 2020, 2021 and 2022 with included all important facts about EFMI activities during past, especialy during the mandate of Alfred Winter as Secretary from 2014 until 2022. It was the first time that all important facts about EFMI were completed at the one place and we decided to published it as some kind of historical bachground of EFMI for people who will continue managing EFMI Council and EFMI Board activities in the future.In this issue we also involved information about new elected Honorry Fellows during last three years and also obituaries about members who passed away, but their names need to be mentioned regarding its important contributions in the development of Medical informatics globaly and in its national organizatios, Some of chairs of Working Groups contributed with their reports in the past year who were actively involved in the development of Medical informatics in their countries, but also worldwide.

The idea for establishing “EFMI Inside” Newsletter was born in Lyon in August 2019, during “MEDINFO 2019” Conference and EFMI Council meeting, when Catherine Chronaki, Izet Masic, and some other EFMI Council members discussed and concluded to start with magazine in which we can record important and prompt facts and information about past, current and future activities of European Federation for Medical Informatics (EFMI). EFMI has other types of spreading information about important facts of its activities, as “Reports”, but closely for official Council members, as reports of national and other representatives in EFMI. This publication will be an important and useful resource of EFMI and its activities for everybody who wants to be familiar with Medical informatics development and achievements in all areas of this academic and scientific discipline in European countries, but also, worldwide. In the first issue of of “EFMI Inside” readers can find contributions of influential medical informatics persons, former or current EFMI Council members - Presidents or Chairs of Working Groups, Honorary Fellows, and other EFMI members who were actively involved in the development of Medical informatics in their countries, but also worldwide. A lot of facts “inside” of the ”newsletter” was not available and visible on the way like presented in this issue.

The idea for establishing this kind of publication, named as “EFMI Inside” Newsletter was born in Lyon in August 2019, during “MEDINFO 2019” Conference and EFMI Council meeting, when Catherine Chronaki, Izet Masic, Arriel Benis, Paris Gallos, Lacramiora Stoicu-Tivadar, Alfred Winter and some other EFMI friends discussed and concluded to start with some kind of magazine in which we can record important and prompt facts and information about past, current and future activities of the European Federation for Medical Informatics (EFMI) available for readers worldwide online and in print. EFMI has other types of spreading information about important facts of its activities, such as “Reports”, addressing mostly EFMI Council members, presented by national representatives and working group chairs in EFMI. This publication will be an important and useful resource of EFMI and its activities for everybody who wants to be familiar with Medical informatics development and achievements in all areas of this academic and scientific discipline in European countries, but also, worldwide. In the first issue of of “EFMI Inside” readers can find contributions of influential medical informatics persons, former or current EFMI Council members: Presidents or Chairs of Working Groups, Honorary Fellows, and other EFMI members who were actively involved in the development of Medical informatics in their countries, but also worldwide. A lot of facts and stories “inside” EFMI are shared for the first time in this newsletter, to look back and think about the future of Medical Informatics in a rapidly changing world. All suggestions and new ideas for the next issues will be appreciated.

Health professionals are able to make right decision in right time only if they posses prompt, accurate and up to date information about health status of patients and general population. They also need knowledge and tools, computer and information technologies, for successful management of huge amount of information. Efficient management of information is of crucial importance for health policy and decision-making process, and to produce high quality results in public health and healthcare delivery. The book presents an original effort to summarize the basic knowledge about the history of medical informatics and informatics education in Europe and broader, development stages and influence of computer sciences on development of medical informatics. In addition, history and development of medical informatics in Croatia and in Bosnia and Herzegovina is also presented, as well as some basic facts about the establishment, importance and activities of the two key international associations–IMIA and EFMI. A broad list of 36 key actors, with brief biographies and photos, is included, as the most influential scientists and doyens in development of medical informatics worldwide. The authors of the book pay special tribute to four corypheés of medical informatics–Morris F. Collen, François Grémy, Peter L. Reichertz and Jean-Claude Healy. The book is fulfilling an important gap revealing the history and emphasizing the importance of medical informatics as a new scientific discipline with very fast development and implementation in health care sector. Health informatics is contributing remarkably in everyday practice of medical and public health professionals, in efficient management of huge and increasing amount of health information and general and specific medical knowledge toward improved quality of health care, as well as to professional and scientific competitiveness in Europe and broader. The knowledge of information technology is now part of general literacy. The 264 pages are distributed in 14 chapters with references and consulted literature added to each chapter. The book is directed toward medical and other professionals in biomedicine, especially the young doctors. The book can be used by students at all levels, from undergraduate to postgraduate master and doctoral studies, and professionals in various clinical disciplines and public health. The book can also be useful as a guideline for all medical and other professionals in biomedicine in conducting everyday activities and promoting of their professional and research work. Skopje, August 2014 Prof. Doncho Donev, MD, PhD CONTRIBUTIONS TO THE HISTORY OF MEDICAL INFORMATICS

Objective: The aim of this study is to confirm the effect of one month dietary treatment on the level serum lipids (cholesterol and tryglicerides) and aminotransferases in overweight patients aged over 50 years. Methods: In agreement with the respondents we requested that they immediately only reduce consumption and that in the reporting period use only food without the use of pharmacotherapy (fat lowering agents and lipid lowering medications). The reason for this assumption is that there is physiological variation for biochemical and hematological examinations by number of internal and external influences determine the size of physiological changes, as well as the necessity of the necessary concentration of certain nutrients for basal metabolism, and function of the body–cells or metabolites. These same subjects, we monitored the frequency of the results, the results of blood glucose, cholesterol, triglycerides, aminotransferase, acidum uricum creatinine after 1 month. The study was carried out on a targeted sample of 10 respondents in the Primary health care center in Gracanica for a period of 30 days. The tests on this sample were conducted survey on health status and nutrition, HIV treatment and diagnosis. Findings: Thee results show that there is an increased number of obese subjects. The paper analyzes the results of biochemical tests in subjects aged over 50 years. On the target medical and biochemical laboratory diagnostic examinations in 10 subjects of both sexes were observed: elevated results of blood glucose, cholesterol, triglycerides, aminotransferase, uric acid and creatinine. It was also observed the fact that most patients was with increased body mass (BMI = and> 25). It has been observed continuous decline or normalization of laboratory test results after one month. Conclusion: There is a growing number of people who are overweight (BMI 25-30) and obese (BMI> 30) due to poor habits, which is dominated by excessive calorie intake. Due to the increased supply of food nutrients: glucose and/or triglyceride, cholesterol, protein in the body, there is increase in the metabolism of carbohydrates, proteins, nonprotein compounds, purine and lipid, with an intense oxidative processes in the mitochondria in particular fat cells and liver disorder utilization of glucose, lipids, purine. As a consequence, the pathological results: higher levels of glucose in the blood, cholesterol, triglycerides, uric acid, creatinine and aminotransferase were observed.

Disclosure of potential conflicts of interest (COI) is used by biomedical journals to guarantee credibility and transparency of the scientific process. COI disclosure, however, is not systematically nor consistently dealt with by journals. Recent joint editorial efforts paved the way towards the implementation of uniform vehicles for COI disclosure. This paper provides a comprehensive editorial perspective on classical COI-related issues. New insights into current COI policies and practices among European Society of Cardiology national cardiovascular journals, as derived from a cross-sectional survey using a standardised questionnaire, are discussed.