W. Cross, I. Lyskjær, Christopher Davies, Abigail Bunkum, A. Rocha, Tom Lesluyes, F. Amary, R. Tirabosco, C. Naceur-Lombardelli, S. Hessey, Kai-Ke-En Shiu, J. Bridgewater, D. Hochhauser, Martin D. Forster, Siow-Ming Lee, T. Ahmad, D. Papadatos-Pastos, Sam M. Janes, K. Enfield, N. Mcgranahan, Ariana Huebner, Sergio Quezada, Stephan Beck, Peter Parker, T. Enver, R. Hynds, D. Pearce, M. Falzon, Ian Proctor, Ron Sinclair, Chi-Wah Lok, Zoe Rhodes, D. Moore, T. Marafioti, M. Mitchison, P. Ellery, Monica Sivakumar, M. Linch, Sebastian Brandner, A. Rowan, C. Hiley, S. Veeriah, H. Shaw, G. Attard, A. Toncheva, Paulina Prymas, T. Watkins, Chris Bailey, Carlos Martínez-Ruiz, K. Litchfield, M. al-Bakir, N. Kanu, S. Ward, Emilia L. Lim, J. Reading, B. Chain, B. T. Trujillo Alba, T. Watkins, M. Akay, D. Biswas, O. Pich, M. Dietzen, C. Puttick, Emma C. Colliver, A. Magness, M. Angelova, J. Black, O. Lucas, William Hill, Wing Liu, A. Frankell, Neil Magno, Foteini Athanasopoulou, R. Salgado, Claudia Lee, Kristiana Grigoriadis, O. Al-Sawaf, Takahiro Karasaki, I. Noorani, S. Benafif, Vittorio Barbè, S. Bola, O. Vainauskas, A. Wingate, Daniel Wetterskog, M. Hasan, S. Lise, Gianmarco Leone, A. Jayaram, C. Alifrangis, U. McGovern, K. Thol, Samuel Gamble, S. K. Ung, T. Sahwangarrom, Claudia Peinador Marin, S. Wong, Piotr Pawlik, J. Lam, Corentin Richard, R. Vendramin, K. Dijkstra, J. Rane, J. Nicod, Rija Zaidi, F. Gishen, A. Tookman, P. Stone, Caroline Stirling, S. Turajlic, James Larkin, Lisa Pickering, A. Furness, Kate Young, W. Drake, K. Edmonds, N. Hunter, Mary Mangwende, K. Pearce, L. Au, L. Spain, Scott T. C. Shepherd, Hai-Xi Yan, B. Shum, Z. Tippu, Brian Hanley, C. Spencer, Max Emmerich, Camille L. Gerard, Andreas M. Schmitt, L. Del Rosario, E. Carlyle, C. Lewis, L. Holt, Analyn Lucanas, M. OFlaherty, S. Hazell, H. Mudhar, Christina Messiou, A. Latifoltojar, A. Fendler, F. Byrne, Husayn Pallinkonda, Irene Lobon, Alexander Coulton, A. Cattin, Da-Qi Deng, G.-G. Feng, Andew Rowan, N. Yousaf, Sanjay Popat, Olivia Curtis, C. Milner-Watts, Gordon Stamp, E. Nye, A. Murra, Justine Korteweg, Denise Kelly, L. Terry, Jennifer Biano, Kema Peat, Kayleigh Kelly, Peter W. S. Hill, D. Josephs, S. Irshad, James Spicer, U. Mahadeva, A. Gréen, Ruby Stewart, N. Wright, Georgina Pulman, R. Mitu, Sherene Phillips-Boyd, D. Enting, Sarah Rudman, Sharmistha Ghosh, Lena Karapagniotou, E. Pintus, A. Tutt, Sarah Howlett, J. Brenton, Carlos Caldas, Rebecca Fitzgerald, M. Jimenez-Linan, E. Provenzano, A. Cluroe, Anna Paterson, Sarah J. Aitken, K. Allinson, G. Stewart, U. McDermott, E. Beddowes, Tim Maughan, Olaf Ansorge, P. Campbell, P. Roxburgh, S. Fraser, Kevin G. Blyth, J. Le Quesne, Matthew Krebs, F. Blackhall, Y. Summers, P. Oliveira, A. Ortega-Franco, C. Dive, Fabio Gomes, M. Carter, Joanne Dransfield, Anne Thomas, D. Fennell, J. Shaw, Babu Naidu, S. Baijal, B. Tanchel, G. Langman, Andrew Robinson, Martin Collard, P. Cockcroft, C. Ferris, H. Bancroft, A. Kerr, Gary Middleton, J. Webb, S. Kadiri, P. Colloby, B. Olisemeke, Rodelaine Wilson, I. Tomlinson, Sanjay Jogai, Samantha K. Holden, Tânia Fernandes, I. McNeish, B. Hampton, Mairead McKenzie, A. Hackshaw, A. Sharp, Kitty Chan, L. Farrelly, Hayley Bridger, R. Leslie, M. Jamal-Hanjani, C. Swanton, N. Pillay, Simone Zaccaria, Adrienne M. Flanagan, P. van Loo
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26. 11. 2025.
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect either relaxed positive selection for the mutant IDH1 locus, or negative selection for the hypermethylation phenotype later in tumor evolution. This finding highlights the challenge for therapeutic intervention by mutant IDH1 inhibitors in chondrosarcoma.