411 The role of combined multichannel intraluminal impedance-pH monitoring in infants with BRUE (brief, resolved, unexplained event)
The data on the relationship on gastroesophageal reflux (GER) and brief resolved unexplained events (BRUE) in infants are scarce. The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance-pH (MII-pH) monitoring in children with suspected GER-related BRUE. Infants hospitalized due to BRUE and who were referred for 24-hour MII-pH monitoring from January 2012 to September 2017 were prospectively included in the study. All children underwent 24-hour MII-pH monitoring using a MIIpH ambulatory system (Ohmega, MMS, Enschede, Netherlands). The impedance recordings were analyzed using criteria described in a consensus statement on indications, methodology and interpretation of combined MII-pH monitoring in children. Twenty-one infants (mean age 4.7 months; range 0.9 to 8.9 months; male/female 10/11) participated in the study. Irregular breathing/apnea associated with GER was found in 10 (52.4%) of infants. Based on RI on pH-metry alone only 7 (33.3%) infants would be diagnosed with GERD. More than 100 GER episodes detected by MII were found in 10 (47.6%) infants. Nineteen percent of infants had GERD diagnosed based on both pH-metry and MII. Acid and non-acid reflux seems to have a significant role in the pathogenesis of GER-related BRUE.