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Nicola Barban, R. Jansen, R. de Vlaming, A. Vaez, Jornt J. Mandemakers, Felix C. Tropf, Xia Shen, James F. Wilson, D. Chasman, I. Nolte, V. Tragante, S. W. van der Laan, John R. B. Perry, A. Kong, T. Ahluwalia, E. Albrecht, L. Yerges-Armstrong, G. Atzmon, K. Auro, K. Ayers, Andrew Bakshi, D. Ben-Avraham, K. Berger, A. Bergman, Lars Bertram, L. Bielak, G. Bjornsdottir, M. Bonder, L. Broer, M. Bui, C. Barbieri, A. Cavadino, J. Chavarro, C. Turman, M. P. Concas, H. Cordell, G. Davies, P. Eibich, N. Eriksson, T. Esko, J. Eriksson, F. Falahi, J. Felix, M. Fontana, L. Franke, I. Gandin, A. Gaskins, C. Gieger, E. Gunderson, Xiuqing Guo, C. Hayward, Chun-Yan He, E. Hofer, Hong-Yan Huang, Peter K. Joshi, S. Kanoni, R. Karlsson, S. Kiechl, A. Kifley, A. Kluttig, P. Kraft, V. Lagou, C. Lecoeur, J. Lahti, R. Li-Gao, P. Lind, Tian Liu, E. Makalic, Crysovalanto Mamasoula, Lindsay K. Matteson, H. Mbarek, P. McArdle, George Mcmahon, S. F. W. Meddens, E. Mihailov, Mike B. Miller, S. Missmer, C. Monnereau, P. J. van der Most, Ronny Myhre, M. Nalls, T. Nutile, Kalafati Ioanna Panagiota, E. Porcu, I. Prokopenko, K. Rajan, J. Rich-Edwards, C. A. Rietveld, A. Robino, L. Rose, R. Rueedi, K. Ryan, Y. Saba, D. Schmidt, Jennifer A. Smith, L. Stolk, E. Streeten, A. Tönjes, G. Thorleifsson, S. Ulivi, J. Wedenoja, J. Wellmann, Peter Willeit, Jie Yao, L. Yengo, Jing-Hua Zhao, Wei Zhao, D. Zhernakova, N. Amin, Howard F. Andrews, B. Balkau, N. Barzilai, Sven Bergmann, G. Biino, H. Bisgaard, K. Bønnelykke, D. Boomsma, J. Buring, Harry Campbell, S. Cappellani, M. Ciullo, S. Cox, F. Cucca, Toniolo Daniela, G. Davey-Smith, I. Deary, G. Dedoussis, P. Deloukas, C. M. van Duijn, Eco J. C. de Geus, J. G. Eriksson, Denis A. Evans, J. Faul, Sala Cinzia Felicita, P. Froguel, Paolo Gasparini, G. Girotto, H. Grabe, K. Greiser, P. Groenen, H. D. de Haan, J. Haerting, T. Harris, A. Heath, K. Heikkilä, Albert Hofman, G. Homuth, E. Holliday, J. Hopper, E. Hyppönen, B. Jacobsson, V. Jaddoe, M. Johannesson, A. Jugessur, M. Kähönen, E. Kajantie, S. Kardia, B. Keavney, I. Kolčić, P. Koponen, P. Kovács, F. Kronenberg, Z. Kutalik, Martina La Bianca, G. Lachance, W. Iacono, Sandra Lai, T. Lehtimäki, D. Liewald, C. Lindgren, Yong-Mei Liu, Robert N. Luben, M. Lucht, R. Luoto, P. Magnus, P. Magnusson, N. Martin, M. McGue, R. McQuillan, S. Medland, C. Meisinger, D. Mellström, A. Metspalu, Traglia Michela, L. Milani, Paul A. Mitchell, G. Montgomery, D. Mook-Kanamori, R. de Mutsert, E. Nøhr, C. Ohlsson, J. Olsen, Ken K. Ong, L. Paternoster, A. Pattie, B. Penninx, M. Perola, P. Peyser, M. Pirastu, O. Polašek, C. Power, J. Kaprio, L. Raffel, K. Räikkönen, O. Raitakari, P. Ridker, S. Ring, Kathryn Roll, I. Rudan, D. Ruggiero, D. Rujescu, V. Salomaa, D. Schlessinger, H. Schmidt, Reinhold E. Schmidt, N. Schupf, J. Smit, R. Sorice, Tim D. Spector, J. Starr, D. Stöckl, K. Strauch, M. Stumvoll, M. Swertz, U. Thorsteinsdóttir, A. Thurik, N. Timpson, A. Tönjes, J. Tung, A. Uitterlinden, S. Vaccargiu, J. Viikari, V. Vitart, H. Völzke, P. Vollenweider, D. Vuckovic, Johannes Waage, G. Wagner, Jie-Jing Wang, N. Wareham, D. Weir, G. Willemsen, J. Willeit, A. Wright, K. Zondervan, K. Stefánsson, R. Krueger, James J. Lee, Daniel J. Benjamin, D. Cesarini, P. Koellinger, M. den Hoed, H. Snieder, M. Mills
133 1. 10. 2016.

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.


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