2
1. 10. 2023.
Impact of follow ups, time interval and study duration in diffusion & myelin MRI clinical study in MS
Highlights • Changes over time from 3 MRIs are similar to those obtained from 5 MRIs.• Some differences are seen in the RR-MS dataset, but not in the healthy dataset.• The associations with the clinical outcomes are affected by the study design.• The effect of the design strategy is bundle- and MRI measure-dependent.• The optimal design will depend on the dynamics of change in the target population.