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5. 10. 2022.
Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration
In a recent study published in Nature Serger connected intermittent fasting (IF) to gut microbiome alterations and enhanced peripheral nerve regeneration following injury. 1 Fasting has been purported to have neuroregenerative effects, but the underlying mechanisms remained unclear. The authors found that IF-induced elevation of IPA (a microbiome-derived metabolite) promotes neutrophil in fi ltration into the dorsal root ganglia (DRG), which enhances the regeneration of sciatic nerve fi bers 1). 2 for