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Constance H. Li, S. Prokopec, Ren X. Sun, Fouad Yousif, N. Schmitz, Fatima Gurnit Peter J. Andrew V. Paul C. Peter J. David K Al-Shahrour Atwal Bailey Biankin Boutros Campbell , F. Al-Shahrour, Gurnit Atwal, Peter Bailey, A. Biankin, Paul C. Boutros, P. Campbell, D. Chang, S. Cooke, Vikram Deshpande, B. Faltas, W. Faquin, L. Garraway, G. Getz, S. Grimmond, Syed Haider, K. Hoadley, W. Jiao, Vera B. Kaiser, R. Karlić, Mamoru Kato, Kirsten Kübler, A. Lazar, Constance H. Li, David N. Louis, Adam A. Margolin, Sancha Martin, Hardeep Nahal-Bose, G. P. Nielsen, S. Nik-Zainal, L. Omberg, Christine P'ng, Marc D. Perry, P. Polak, Esther Rheinbay, M. Rubin, C. Semple, Dennis C. Sgroi, T. Shibata, Reiner Siebert, Jaclyn Smith, Lincoln Stein, Miranda D. Stobbe, Kevin Thai, Derek W. Wright, Chin-Lee Wu, Ke Yuan, Junjun Zhang, Paul C. Boutros, Lauri A. Federico Adam Hiroyuki David J. Nishant Keun So Aaltonen Abascal Abeshouse Aburatani Adams Agrawal, L. Aaltonen, F. Abascal, Adam Abeshouse, H. Aburatani, D. J. Adams, N. Agrawal, K. Ahn, S. Ahn, H. Aikata, Rehan Akbani, K. Akdemir, H. Al-Ahmadie, S. Al-Sedairy, M. Alawi, Monique Albert, K. Aldape, L. Alexandrov, Adrian Ally, K. Alsop, Eva G. Álvarez, F. Amary, S. Amin, Brice Aminou, O. Ammerpohl, M. Anderson, Y. Ang, D. Antonello, Pavana Anur, S. Aparicio, Elizabeth L. Appelbaum, Y. Arai, Axel Aretz, K. Arihiro, S. Ariizumi, J. Armenia, L. Arnould, S. Asa, Y. Assenov, S. Aukema, J. Auman, M. R. Aure, P. Awadalla, M. Aymerich, Gary D Bader, A. Baez-Ortega, Matthew H. Bailey, M. Balasundaram, S. Balu, P. Bandopadhayay, R. Banks, S. Barbi, A. Barbour, J. Barenboim, J. Barnholtz-Sloan, Hugh Barr, E. Barrera, John M. S. Bartlett, Javier Bartolome, C. Bassi, O. Bathe, D. Baumhoer, P. Bavi, S. Baylin, Wojciech Bazant, D. Beardsmore, Timothy A Beck, S. Behjati, A. Behren, Beifang Niu, C. Bell, S. Beltrán, Christopher J. Benz, A. Berchuck, A. Bergmann, E. Bergstrom, B. Berman, D. Berney, S. Bernhart, R. Beroukhim, Mario Berrios, S. Bersani, Johanna Bertl, M. Betancourt, Vinayak Bhandari, S. Bhosle, M. Bieg, D. Bigner, Hans-Eugen Binder, E. Birney, M. Birrer, N. Biswas, B. Bjerkehagen, T. Bodenheimer, L. Boice, G. Bonizzato, J. D. de Bono, Arnoud Boot, Moiz Bootwalla, Å. Borg, A. Borkhardt, Keith A. Boroevich, I. Borozan, Christoph Borst, M. Bosenberg, Mattia Bosio, J. Boultwood, G. Bourque, G. Bova, D. Bowen, R. Bowlby, D. Bowtell, S. Boyault, R. Boyce, Jeffrey H. Boyd, A. Brazma, P. Brennan, D. Brewer, A. Brinkman, Rob Bristow, R. Broaddus, J. Brock, M. Brock, A. Broeks, Angela N. Brooks, Denise Brooks, B. Brors, S. Brunak, T. Bruxner, A. Bruzos, Alex Buchanan, I. Buchhalter, C. Buchholz, S. Bullman, H. Burke, B. Burkhardt, K. Burns, John P. Busanovich, C. D. Bustamante, A. Butler, A. Butte, Niall J. Byrne, A. Børresen-Dale, Samantha J. Caesar-Johnson, Andy Cafferkey, D. Cahill, C. Calabrese, Carlos Caldas, F. Calvo, Niedzica Camacho, E. Campo, C. Cantù, S. Cao, T. Carey, Joana Carlevaro-Fita, R. Carlsen, I. Cataldo, M. Cazzola, J. Cebon, R. Cerfolio, D. Chadwick, D. Chakravarty, D. Chalmers, Calvin Wing Yiu Chan, Kin Chan, M. Chan-Seng-Yue, V. Chandan, S. Chanock, L. Chantrill, A. Chateigner, N. Chatterjee, K. Chayama, Hsiao-wei Chen, Jieming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, A. Cherniack, J. Chien, Y. Chiew, S. Chin, Juok Cho, Sunghoon Cho, J. Choi, Wan Choi, C. Chomienne, Zechen Chong, S. Choo, A. Chou, Angelika N. Christ, E. Christie, E. Chuah, C. Cibulskis, K. Cibulskis, S. Cingarlini, P. Clapham, A. Claviez, S. Cleary, N. Cloonan, Marek Cmero, C. Collins, Ashton A Connor, C. Cooper, L. Cope, V. Corbo, M. Cordes, S. Cordner, I. Cortés-Ciriano, K. Covington, P. Cowin, Brian Craft, David W Craft, C. Creighton, Yupeng Cun, Erin E. Curley, I. Cutcutache, Karolina M. Czajka, B. Czerniak, Rebecca A. Dagg, Ludmila V. Danilova, M. Davi’, Natalie R. Davidson, Helen R Davies, I. Davis, B. Davis-Dusenbery, K. Dawson, Francisco M. De La Vega, Ricardo De Paoli-Iseppi, T. DeFreitas, A. D. Dei Tos, O. Delaneau, John A. Demchok, J. Demeulemeester, German M. Demidov, Deniz Demircioğlu, N. Dennis, R. Denroche, S. Dentro, N. Desai, Vikram Deshpande, A. Deshwar, C. Desmedt, J. Deu-Pons, Noreen Dhalla, N. Dhani, P. Dhingra, R. Dhir, Anthony Dibiase, K. Diamanti, L. Ding, Shuai Ding, Huy Q. Dinh, L. Dirix, H. Doddapaneni, Nilgun Donmez, Michelle Dow, R. Drapkin, O. Drechsel, Ruben M. Drews, Serge Serge, T. Dudderidge, Ana Dueso-Barroso, Andrew J. Dunford, Michael Dunn, L. Dursi, F. Duthie, K. Dutton-Regester, Jenna Eagles, D. Easton, Stuart D. Edmonds, Paul A. Edwards, S. Edwards, R. Eeles, A. Ehinger, Juergen Eils, R. Eils, A. El-Naggar, M. Eldridge, K. Ellrott, S. Erkek, G. Escaramís, S. M. G. Espiritu, X. Estivill, D. Etemadmoghadam, J. Eyfjord, D. Fan, Yu Fan, W. Faquin, Claudiu Farcas, M. Fassan, Aquila Fatima, F. Favero, Nodirjon Fayzullaev, Ina Felau, S. Fereday, M. Ferguson, Vincent Ferretti, L. Feuerbach, M. Field, J. Fink, G. Finocchiaro, C. Fisher, M. Fittall, Annarose Fitzgerald, R. Fitzgerald, A. Flanagan, N. Fleshner, Paul Flicek, J. Foekens, K. Fong, Nuno A. Fonseca, Christopher S. Foster, Natalie S. Fox, M. Fraser, S. Frazer, M. Frenkel-Morgenstern, William Friedman, J. Frigola, C. Fronick, Akihiro Fujimoto, Masashi Fujita, M. Fukayama, L. Fulton, R. Fulton, Mayuko Furuta, P. Futreal, Anja Füllgrabe, S. Gabriel, S. Gallinger, C. Gambacorti-Passerini, Jianjiong Gao, Shengjie Gao, Ø. Garred, Erik P. Garrison, D. W. Garsed, Nils Gehlenborg, J. Gelpí, J. George, D. Gerhard, C. Gerhauser, J. Gershenwald, Marc H. Gerstein, M. Gerstung, Mohammed J. R. Ghori, R. Ghossein, N. Giama, R. Gibbs, A. Gill, P. Gill, D. Giri, D. Głodzik, V. Gnanapragasam, Maria Elisabeth Goebler, M. Goldman, Carmen Gomez, Santiago Gonzalez, A. González-Pérez, D. Gordenin, J. Gossage, K. Gotoh, R. Govindan, D. Grabau, J. S. Graham, R. Grant, A. Green, Eric D. Green, Liliana Greger, N. Grehan, Sonia Grimaldi, R. Grossman, A. Grundhoff, G. Gundem, Qianyun Guo, Manaswi Gupta, S. Gupta, I. Gut, M. Gut, Jonathan Göke, G. Ha, A. Haake, D. Haan, S. Haas, K. Haase, James E. Haber, N. Habermann, Faraz Hach, Natsuko Hama, F. Hamdy, Anne Hamilton, M. P. Hamilton, Leng Han, George B. Hanna, M. Hansmann, N. Haradhvala, O. Harismendy, Ivon Harliwong, A. Harmanci, E. Harrington, Takanori Hasegawa, D. Haussler, Steve Hawkins, S. Hayami, Shuto Hayashi, D. Hayes, S. Hayes, N. Hayward, S. Hazell, Yao He, Allison P. Heath, S. Heath, D. Hedley, A. Hegde, David I Heiman, Michael C. Heinold, Zachary J. Heins, Lawrence E Heisler, E. Hellstrom-Lindberg, M. Helmy, Seong Gu Heo, Austin J. Hepperla, J. M. Heredia-Genestar, C. Herrmann, P. Hersey, J. Hess, H. Hilmarsdóttir, Jonathan Hinton, S. Hirano, N. Hiraoka, A. Hobolth, Ermin Hodzic, J. Hoell, S. Hoffmann, Oliver Hofmann, Andrea E Holbrook, A. Holik, M. Hollingsworth, O. Holmes, R. Holt, Chen Hong, E. Hong, Jongwhi H. Hong, G. Hooijer, H. Hornshøj, F. Hosoda, Yong Hou, V. Hovestadt
74 23. 1. 2019.

Sex differences in oncogenic mutational processes

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research. There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.


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