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1. 4. 2024.
WCN24-800 ACUTE KIDNEY INJURY AND SEVERE HYPONATREMIA CAUSED BY CHRONIC SECRETORY DIARRHEA: MCKITTRICK-WHEELOCK SYNDROME
McKittrick-Wheelock syndrome is characterized by secretory diarrhea and severe electrolyte and fluid depletion caused by a large, distal colon, villous adenoma. It was first described in 1940 as a 'pre-renal uremia due to papilloma of the rectum'. Due to its hypersecretory nature, the tumor may cause more than 4 L of secretory diarrhea per day, with a content of sodium that is approximately four times higher than in normal stool. Unbelievably, it can be unreported by patients and thus overlooked as a cause of severe hyponatremia and acute kidney injury.